pharma II test II eicosanoid

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pharma II test II eicosanoid
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2013-04-09 12:04:54
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pharma II test II eicosanoid
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  1. lipoxygenase inhibitor
    zileuton
  2. leukotriene receptor inhibitors
    • zafirlukast
    • montelukast
  3. leukotriene receptor inhibitors and lipoxygenase inhibitors uses
    treat asthma - vasodilation
  4. eicosanoid
    synthetic PGE2
    used as abortifacient
    induction of labor
    gel, controlled-release, vaginal suppository
    dinoprostone - servidil
  5. eicosanoid abortifacient MOA
    softens cervix by increasing proteoglycan content and changing biophysical properties of collagen
  6. eicosanoid
    ind - abortifacient
    oral & vaginal
    misoprostol + mifepristone
  7. eicosanoid
    ind - abortifacient
    intra-amniotic inj., IM
    AE - CV collapse, GI toxicity, bronchoconstriction
    carboprost tromethamine
  8. eicosanoid
    ind - dysmenorrhea
    NSAIDs
  9. MOA of NSAIDs for Tx of dysmenorrhea
    inhibits prostaglandin formation
  10. eicosanoid
    ind - erectile dysfunction
    intracavernosal injection or urethral suppository
    A/E - penile pain, priapism
    alprostadil - caverject
  11. MOA of alprostadil for erectile dysfunction
    relaxes smooth muscle of corpora cavernosa
  12. eicosanoid
    ind - pulmonary hypertension
    short half life
    continuous infusion
    prostacyclin - flolan
  13. eicosanoid
    ind - pulmonary hypertension
    inhalation, IV
    T1/2 - 30 min
    iloprost
  14. eicosanoid
    ind - pulmonary hypertension
    SC, IV
    t 1/2 - 4h
    treprostinil - remodulin
  15. MOA of eicosanoid for pulmonary hypertension
    powerful vasodilator & inhibitor of platelet-aggregation
  16. eicosanoid
    ind - patent ductus arteriosus
    used to maintain before surgery in congenital heart disease
    alporstadil (PGE1)
  17. eicosanoid
    ind - patent ductus arteriosus
    used to close the duct in delayed process
    COX inhibitors - indomethacin
  18. eicosanoid
    ind - glaucoma
    PGF2alpha derivative
    latanoprost - xalatan
  19. eicosanoid
    ind - glaucoma
    3 drugs
    AE - pigmentation of the iris & eyelashes, drying eyes, conjunctivitis
    • bimatoprost - lumigan
    • travoprost - travatan
    • unoprostone - rescula
  20. MOA of eicosanoid for glaucoma
    • act at the FP-receptors
    • administered into conjunctival sac
  21. 4 relaxant channels
    • IP
    • EP2
    • EP4
    • DP1
  22. 3 contractile receptors
    • TP
    • FP
    • EP
  23. 1 inhibitory channel
    EP3
  24. eicosanoid
    ind - chronic idiopathic constipation & irritable bowel syndrome with const.
    lubiprostone - amitiza
  25. eicosanoid
    ind - dialysis
    moa - (PGI2) inhibits platelet aggregation in dialysis machine
    epoprostenol - flolan

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