pharma II test III histamine

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211872
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pharma II test III histamine
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2013-04-11 08:49:09
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pharma II test III histamine
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  1. what is histamine formed from and metabolized by
    • L-histidine
    • histidine decarboxylase
  2. metabolism of histamine
    MAO and diamine-oxidase into metabolites (methyhistamine & imidazole acetic acid)
  3. triple response caused by intradermal injection of histamine
    • flush
    • wheal
    • flare
  4. histamine receptor
    widespread expression
    intracellualr signaling=Gaq
    second messengers 
       increases IP3,DAG, Ca
    functions
       general
       CNS
       allergic inflammation
    H1
  5. histamine receptor
    located GI mucosa parietal cells
    signaling = Gas
    second messengers
       increases cAMP,Ca,phospholipase C
    functions
       increased gastric acid secretion
       bronchodilation
    H2
  6. histamine receptor
    located pre-synaptic: brain
    signaling = Gi
    second messengers
       decreases cAMP & Ca
    H3
  7. histamine receptor
    located blood cells
    signaling = Gi
    second messengers
       decreases cAMP & Ca
    H4
  8. histamine antagonist at the alpha-receptor
    can cause orthostatic HoTN
    promethazine
  9. histamine antagonist at the serotonin-receptor
    cyproheptadine
  10. histamine antagonist for local anesthesia
    • diphenhydramine
    • promethazine
  11. H1 antagonists for insomnia
    • diphenhydramine
    • doxylamine
    • pyrilamine
  12. H1 antagonist for perioperative sedation
    • diphenhydramine
    • hydroxyzine
    • promethazine
    • cyproheptadine
  13. H1 antagonist that cause torsades de pointes
    • terfenadine
    • astemizole
  14. H1 antagonist DI
    • BZ
    • alcohol
    • CYP inhibitors - ketoconazole
    •     first gens and loratidine
  15. H2 antagonist that induces GI contraction
    nizatidine
  16. H1 second gens
    • acrivastine
    • cetirizine
    •    levocetirizine
    • loratidine
    •    desloratidine
    • fexofenadine
  17. histamine release inhibitors
    • cromolyn
    • nedocromil
  18. histamine receptor blocker
    omalzumab - xolair
  19. histamine physiologic antagonist
    epinephrine
  20. H2 antihistamines
    • famotidine
    • cimetidine
    • ranitidine
    • nizatidine
  21. H2 antagonist that doesn't block alcohol metabolism
    famotidine
  22. second gen antagonist metab by CYP3A4
    loratidine

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