PTG 105-Exam 3- Lecture 18-1

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  1. What is the name for a precancerous lesion of the cervix?
    Cervical intraepithelial neoplasm
  2. What is another term for Cervical intraepithelial neoplasm?
    Precancerous lesion of the Cervix
  3. What has dramatically lowered the incidence of Cervical intraepithelial Neoplasms?
    PAP smear
  4. PAP smears have helped to lower the incidence of what disease?
    Cervical intraepithelial neoplasms
  5. CIN stands for?
    Cervical intraepithelial neoplasia
  6. What specific type of precancerous lesion of the cervix is Cervical intraepithelial neoplasia?
    Squamous dysplasia
  7. What is the general timeline for a Cervical intraepithelial neoplasia to progess to an invasive carcinoma?
    May be twenty years or more
  8. What virus is associated with Cervical intraepithelial neoplasia?
    HPV (human papilloma virus)
  9. What is the causative agent of Condyloma acuminate?
  10. What is Condyloma acuminata?
    Genital warts
  11. What is another term for genital warts?
    Condyloma acuminata
  12. What can HPV cause?
    • Condyloma acuminate
    • Cervical Cancer
  13. Condyloma acuminata and cervical cancer can both be caused by what virus?
  14. Lesions associated with HPV can occur on what body parts?
    Vulva, Vagina and cervix
  15. Describe the characteristics associated with an HPV infection with strains 6 and 11:
    • Low risk
    • Exophyitic warty growth
  16. Which HPV strains are associated with low risk and exophytic warty growths?
    Strains 6 and 11
  17. Which HPV strains are associated with High risk of cancer and flat lesions?
    Strains 16 and 18
  18. Strains 16 and 18 of HPV have what general characteristics?
    High risk of cancer and flat lesions
  19. What are the different grades of CIN?
  20. What are the characteristics of CIN I grade?
    Mild dysplasia
  21. What are the characteristics of CIN II?
    Moderate dysplasia
  22. What are the characteristics of CIN III?
    Severe dysplasia/carcinoma in situ
  23. Carcinoma in situ is what?
    • Closest thing to having cancer
    • Cancer that is not yet spreading/malignant
  24. What is the worst grade and its characteristics of Cervical Intraepithelial Neoplasia?
    CIN III – severe dysplasia- carcinoma in situ
  25. Koilocytes are seen on what type of test?
    PAP smear
  26. Koilocytes indicate what disease?
    Cervical precancer
  27. Koilocytes look like what?
    • Dark, enlarged irregular nucleus
    • Clear area (perinuclear halo) around the nucleus
  28. How does SIL compare to CIN?
  29. What is SIL used for?
    To grade dysplasia on a PAP smear
  30. What does SIL stand for?
    Squamous Intraepithelial Neoplasia
  31. What is the acronym for the Squamous intraepithelial neoplasia grading system on a PAP smear?
  32. What is the treatment for CIN I?
    Follow up
  33. What is the treatment for CIN II?
    Cone biopsy and LEEP
  34. What is the treatment for CIN III?
    Cone biopsy, LEEP and hysterectomy
  35. What grade of CIN is the treatment a follow up?
    CIN I
  36. What grade of CIN is the treatment LEEP and cone biopsy?
    CIN II
  37. What grade of CIN is the treatment LEEP, cone biopsy and hysterectomy?
  38. What percent of people with SIL end up with no advancement and naturally leads to remission?
  39. What percentage of those found to have SIL have disease progression?
  40. Of those that progress with SIL, what percent develop an invasive cancer?
  41. Of those that progress with SIL what percentage end up with CIN III?
  42. What percent of Cervical cancers are squamous cell carcinoma?
  43. 75-90% of all cervical cancers are what type?
    Squamous cell
  44. What do Cervical cancers arise from?
    Precancerous lesions-CIN/squamous dysplasia
  45. What are the risk factors for Cervical Cancer?
    • HPV
    • Multiple sexual partners
    • Intercourse with a male that has had multiple sexual partners
    • Smoking
    • Immune deficiency
    • Early age of intercourse

    • What is the most common cancer in women worldwide?
    • Cervical cancer-Squamous cell carcinoma
  46. What is the second most common cervical cancer type?
  47. What is the frequency of adenocarcinomas in cervical cancer patients?
    Second most common, makes up most everything that Squamous cell does not.
  48. What is the common age group for cervical cancer?
    • 40-60 years
    • Beginning to increase In younger females

    • What disease is likely for a patient suffering from vaginal discharge, abnormal bleeding and postcoital bleeding?
    • Cervical Cancer
  49. Cervical Cancer manifests itself as what?
    • Postcoital bleeding
    • Abnormal bleeding
    • Vaginal discharge
  50. How is cervical cancer diagnosed?
    Cytology and Biopsy
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PTG 105-Exam 3- Lecture 18-1

PTG 105-Exam 3- Lecture 18-1
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