Lab Final - Lip Balms and Troches

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jcu1
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212257
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Lab Final - Lip Balms and Troches
Updated:
2013-04-10 08:19:13
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Lab Final
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Lab final
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  1. beyond use date for non-aqueous liquids and solid formulations
    no later than 25% of the time remaining till products expiration

    OR

    6 months (whichever comes first)
  2. Beyond use date for water containing oral preparations
    no later than 14 days (stored at cold temps)
  3. beyond use date for topical/dermal/mucosal formulations
    no later than intended duration of therapy

    OR

    30 days (whichever comes first)
  4. Class A/Class III balances are used for what weights?
    loads of 120 mg - 120 g
  5. Class B balances are used for what weights?
    648 mg
  6. what is the minimum weighable quantity (LWQ) for Class A balances?
    120 mg
  7. an electronic balance can weigh between what range?
    0.001 mg to 5 kg
  8. medications and ingredients that have been incorporated into sticks include:
    • local anesthetics
    • sunscreens
    • oncology drugs
    • antivirals
    • antibiotics
  9. what are cold sores/fever blisters caused by?
    herpes simplex virus type 1 (HSV-1)
  10. what does HSV do?
    • invades cells in the epidermis (outer layer of skin)
    • causes fluid-filled blisters around mouth or on lips
  11. relationship between HSV and age?
    infection increases with age
  12. MOA of trigger factors for HSV
    unknown
  13. types of lip balm bases
    • melting bases (for soft sticks)
    • moistening bases (for hard sticks)
  14. melting bases for lip balm - what do they do and what types are there?
    soften at body temp and spread drug/vehicle over the lip

    • soft opaque
    • soft clear
  15. soft opaque bases for lip balm
    • type of melting base for soft sticks
    • waxes, oils, petrolatum, cocoa butter, PEG
  16. soft clear bases for lip balm
    • type of melting base for soft sticks
    • sodium stearate/glycerine mixes, propylene glycol
  17. moistening bases for lip balm
    • bases for hard sticks
    • crystalline powder fused by heat and held together by binder
    • needs moistening for activation
  18. polyethylene glycol description
    non-toxic odorless, neutral, luricating, nonvolatile, and nonirritating
  19. what is polyehtylene glycol used as?
    • solvent
    • dispensing agent
    • ointment
    • suppository bases
    • vehicle
    • tablet excipient
  20. what does PEG in combo with a number mean?
    average molecular weights
  21. PEG's solubility?
    • water soluble
    • soluble in many organic solvents including aromatic hydrocarbons, but not aliphatics
  22. shelf life of lip balm?
    6 months
  23. store lip balm at what temp?
    5-25'
  24. What is a troche?
    • a compressed lozenge
    • designed to dissolve or disentegrate slowly in the mouth
  25. the choice of a troche is limited by what?
    • flavor, dose, chemical incompatability
    • i.e. benzocaine is incompatible with the candy base
  26. the base of a hard lozenge vs. a soft lozenge
    • hard: solid syrup of sugar with adhesive
    • soft: PEG base with soft texture (usually transparent)
  27. Drug release of hard vs. soft lozenge
    • hard: slow, uniform dissolution w/o disintegration
    • soft: can be chewed or dissolved in mouth
  28. the effect of hard vs. soft lozenges
    • hard: local demulcent effect as some excipient are released slowly; spreads uniformly over mucosal surface
    • soft:¬†chewable lozenge has a glycerinated gelatin base (delivers drug to the GIT)
  29. temperature requirements of hard vs soft lozenge
    • hard: needs high temps - not good for thermolabile drug
    • soft: doesn't need high temps
  30. xerostomia; what is it and what causes it
    • dry mouth
    • aging, systemic disease, radiation therapy or medication
  31. how to calibrate a troche mold
    • 1. make sure mold is clean and dry
    • 2. melt enough base to fill the cavities
    • 3. pour into the mold, cool and dry
    • 4. remove lozenges and weigh, dividing the total weight by the number of lozenges
    • 5. gives the average weight of lozenge for that base in the mold
  32. special consideration of troches with a PEG base
    hygroscopic - might soften when exposed to inc temps
  33. stability of a troche
    6 months

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