pharma II test III 5HT

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pharma II test III 5HT
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2013-04-08 19:41:18
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pharma II test III 5HT
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  1. serotonin function in cardiovascular system
    • vasoconstriction (except skeletal muscle and heart)
    • platelet aggregation
    • subendocardial fibroplasia
  2. serotonin function in GI tract
    • contraction of smooth muscle
    • prokinetic effect
    • sever diarrhea in carcinoid syndrome
  3. serotonin function in airway
    bronchoconstriction
  4. serotonin function in skeletal muscle
    malignant hyperthermia
  5. serotonin function in behavior
    • control of sleep-wake cycle
    • aggression and impulsivity
    • anxiety and depression
  6. serotonin function in nervous system
    • neurotransmitter (itch & pain)
    • activates
    •    vomiting center in medulla
    •    enteric nerves
    •    chemoreceptor reflex (bezold-jarisch reflex)
  7. 5-HT1 receptors
    Gi - inhibits adenylyl cyclase, decrease cAMP
  8. 5-HT 2 receptors
    Gq - increases IP3 & DAC
  9. 5-HT 3 receptors
    activates ligand-operated ion channels
  10. 5-HT 4 receptors
    Gs - activates adenylyl cyclase
  11. 4 serotonin agonist
    • triptans 1D,1B
    • buspirone 1A
    • cisapride - propulsid 4
    • SSRIs
  12. MOA of triptans
    • constricts intracranial blood vessels
    • blocks the release of calcitonin gene related peptide (CGRP) in trigeminal nerves
  13. 4 AE of triptans
    • chest discomfort
    • altered sensation (paresthesis, warmth)
    • rebound migraine
    • SC inj - stinging, burning,
    • nasal spray - bitter taste
  14. 5 CI of triptans
    • ischemic heart disease and angina
    • peripheral vascular disease
    • concurrent (24hrs) of ergot or triptan
    • renal or hepatic impairment
    • wolff-parkinson-white syndrome
  15. 4 drug interactions of triptans
    • ergot alkaloids
    • MAOIs
    • SSRI or SNRI - serotonin syndrome
    • eletriptan should not be used w/i 72hrs of strong CYP3A4 inhibitor
  16. serotonin agonist
    indicated for chronic weight management in conjunction with dietary intervention
    lorcaserin - belviq
  17. serotonin antagonist
    blocks (2) and histamine
    ind - carcinoid tumor
           post-gastrectomy dumping syndrome
    cyproheptadine - periactin
  18. serotonin antagonist
    blocks (1c&2)
    inhibits platelet aggregation
    blocks a1-adrenergic receptors
    hypotensive
    • ketanserin
    • ritanserin
  19. serotonin antagonist
    blocks (3)
    ind - N/V associated with surgery and cancer chemo-therapy
    setron's
  20. formed from serotonin in pineal gland
    maintains circadian rhythm
    ind - insomnia, jet lag
    MOA - Gi
    melatonin
  21. ergot acting on the CNS & Pituitary
    • LSD
    • bromocriptine
    • pergolide
  22. ergot acting on uterus
    • ergonovine
    • ergotamine
  23. ergot working on the vessels
    • ergotamine
    • methysergide

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