pharma II test III hypothalamic & pituitary

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pharma II test III hypothalamic & pituitary
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2013-04-08 22:28:41
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pharma II test III hypothalamic pituitary
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pharma II test III hypothalamic & pituitary
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  1. anterior lobe of the piruitary
    adenohypophysis
  2. posterior lobe of pituitary
    neurohypophysis
  3. hypothalamus communication with the anterior pituitary
    releasing regulating factors delivered through portal blood vessels
  4. hypothalamus communication with posterior pituitary
    neuronally
  5. inhibitory factors released in hypothalamus
    • DA
    • somatostatin (SST)
  6. moa of the release of regulation factors
    G protein-GTP complexes activate adenylyl cyclase producing the second messenger cAMP
  7. G protein for GnRH & TRH
    G14
  8. G protein for GHRH,CRH,ACTH,FSH,LH
    Gs
  9. two inhibitory mechanisms of DA
    • reduces adenylyl cyclase activity
    • inhibits prolactin secretion
  10. inhibitory mechanism of SST
    • exerts effects on potassium channel
    • inhibits GH secretion
  11. polypeptide
    secreted by somatotrophs
    moa - activates JAK-STAT pathway
    ind - dwarfism
    growth hormone
  12. 2 growth hormone recombinant products
    • somatropin - humantrope
    • somatrem - protropin
  13. 3 AE of growth hormone recombinant products
    • hyperglycemia
    • hypothyroidism
    • antibodies to GH
  14. drug interactions with GH recombinant products
    glucocorticoids
  15. synthetic IGF analog
    • rinfabate - increlex
    • mecasermin rinfabate - iplex
  16. synthetic GHRH
    ind - diagnose pituitary GH secretory capacity in children
    Sub Q
    sermorelin - geref
  17. 4 growth hormone antagonists
    • somatostatin
    • ocreotide - sandostatin
    • lanreotide - somatuline
    • pegvisomant - somavert
  18. gonadotropins effects on women
    • ovarian follicle development (FSH)
    • ovarian steroidogenesis (FSH,LH)
  19. gonatotropin effects on men
    • regulation of spermatogenesis (FSH)
    • stimulus for testicular androgen production (LH)
  20. 2 FSH analogs
    • urofollitropin - uFSH
    • follitropin alfa and beta
  21. FSH & LH analog
    menotropin - pergonal
  22. 3 LH analogs
    • human chorionic gonadotropin (hCG)
    • chorigonadotropin alfa (rhCG)
    • luteinizing hormone - lutropin alpha
  23. difference between pulsatile and non release of GnRH
    • pulsatile - stimulates release of LH & FSH
    • non - inhibits release of LH & FSH, causing hypogonadism
  24. GnRH analog
    gonadorelin - factrel
  25. 4 formulations of GnRH analogs
    • gonadorelin - lyophilized powder for IC & SC
    • leuprolide - solution SC, micrispheres IM
    • nafarelin - nasal spray
    • goserelin - implantable cylinders, SC, inj
  26. 2 GnRH antagonist
    • ganirelix - antagon
    • cetrorelix acetate - cetrotide
  27. 2 main functions of oxytocin
    • promotes uterine contraction during labor
    • stimulates milk ejection
  28. 3 uses for desmopressin acetate
    • hypothalamic diabetes insipidus
    • nocturnal enuresis
    • coagulopathy
  29. 2 vasopressin antagonist
    • conivaptan - vaprisol
    • tolvaptan - samsca
  30. 2 uses of vasopressin antagonists
    euvolemic and hypervolemic hyponatremia

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