PTG 105 -Exam 3- Lecture 16-5

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PTG 105 -Exam 3- Lecture 16-5
2013-04-09 16:11:48
PTG 105 Exam Lecture 16

PTG 105 -Exam 3- Lecture 16-5
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  1. Carrier state of Hep B is indicated by what?
    Presence of HBs antigens for over 6 months
  2. Anti HBs confers what?
    lifelong immunity
  3. Lifelong immunity for HBs can be conferd by what?
  4. What serum levels indicate active viral replication in Hep B?
    HBe antigen and HBV DNA
  5. HBe antigens and HBV DNA indicate what in a person with Hep B?
    Active disease state, repliating virus
  6. What percent of Hep B sufferers have complete recovery and subclinical disease?
  7. What percent of Hep B sufferers have acute hepatitis, but completely recover?
  8. What percent of Hep B cases end with the person as a healthy carrier?
  9. What percent of Hep B infected individuals have a persistent infection?
  10. Of those Hep B sufferers that have a persistant infection, what percent recover eventually?
  11. Of those Hep B sufferers with a persistant infection, what percent develop chronic hepatitis?
  12. Of the 10% of Hep B sufferers with a chronic infection, 10% develop hepatitis , what percent of those with hepatitis develop cirrhosis?
  13. Massive or fulmitant hepatic failure is a common outcome of Hep B?
    False, it is uncommon
  14. How is an acute infection of Hep B treated?
    no treatment availbale, just supportive
  15. What type of Hep B infection has no treatment available (only supportive)?
    Acute infection
  16. What treatments are availbale for chronic Hep B infection?
    inerferon alpha-2a and anti-virals
  17. What type of Hep B infection can be treated with antivirals and interferon alpha-2a?
    Chronic hep b infection
  18. Hep C is what type of virus?
    DNA virus
  19. What is the incubation period of Hep C?
    2 weeks to 6 months
  20. How does Hep C spread?
    Similar to Hep B (blood, fluids, etc.)
  21. What strain of Hep B causes the most cases of post-transfusion hepatitis?
    Hep C
  22. Hep B or Hep C is more likley to develop into chronicity, Cirhosis and carcinoma?
    Hep C
  23. The symptoms of Hep C are similar to what other Hepatitis strain?
    Hep B
  24. What two main viral strains of hepatitis are most likley to lead to hepatocellular carcinoma?
    B and C
  25. What is the chance of aquiring Hep C from a blood transfusion (currently with advanced screen methods)?
    1 in 2 million units
  26. Before 1992 what was the leading method for aquiring Hep C?
    blood transfusion
  27. How do you screen for Hep C?
    • look for anti-HCV by:
    • EIA or RIBA

    • Tests to detect presence of virus:
    • HCV RNA via PCR
  28. What is RIBA?
    recombinant immunoblot assay
  29. What Hepatits strain would you test for using EIA, RIBA or PCR?
    Hep C
  30. What is the treatment for chronic Hep C?
    pegylated interferon and ribavirin
  31. What Hep strain/type would you treat with pegylated interferon and ribavirin?
    Hep C
  32. What are the characteristics of Hep Delta virus?
    • Requires Hep B for replication
    • Infection only in those with HBV
  33. Which Hepatitis strain requires a current infection of Hep B?
    Hep Delta
  34. HEV is similar to what other hep strain?
    Hep A
  35. Describe the characteristics of Hep E?
    • acute
    • self-limiting
    • no chronicity or carrier state
    • can cause fulmitant hep in preganant women
  36. What Hep strain can cause fulmitant hep in pregnant women?
    Hep E