PTG 105- Exam 3- Lecture 20 - 3
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What is Osteitis fibrosa cystica?
Bone converted to fibrous tissue with cysts
What is the name for bone converted to fibrous tissue with cysts?
Osteitis fibrous cystica
Parathyroid adenoma is the most common cause of what?
What is the most common cause of hyperparathyroidism?
How do you treat parimary hyperparathyroidism?
How do you treat secondary hyperparathyroidism?
treat the primary disease
What are the causes of Hypoparathyroidism?
- surgical removal of parathyroid due to hyperparathyroidism
- removal during thyroidectomy
- congenital absense
What is DiGeorge's syndrome?
Congenital absense of parathyroid gland
What is the name for the congenital absense of the parathyroid gland?
What reasons would you surgically remove teh parathyroid?
- incidental due to removal of thyroid
How does Hpyoparathyroidism manifest itself?
Decreased serum Ca (causes muscle spasms and convulsions)
A person with decreased Ca in the serum and muscle spasms and convulsions might have what disease?
How do you test for Hypoparathyroidism?
Perform lab testing for decreased PTH and Ca
What is the treatment for hyperparathyroidism?
Synthetuc Vitamin D and Ca supplements
What disease can be treated with synthetic Vit. D supplements and Ca supplements?
What three general groups of hormones are produces by the Adrenal cortex?
- Weak androgens
What general group of hormones are produced in the adrenal medulla?
What is the purpose of mineralcorticoids?
Na and K balance
What is the purpose of Glucocorticoids?
- raise blood glucose
- inhibit inflammation
- adapt to long term stress
WHat do catecholamines do?
Increae blood pressure HR and deal with short term stress
Zona glomerulaosa produces what general hormones?
Zona fasciculata produce what general types of hormones?
Sex steroid and glucocorticoids
Zona reticularis produces what types of hormones?
Glucocorticoids and sex steroids
Name four diseases of the adrenal glands
- Addison's disease
- Cuching's disease
- Conn's disease
- Neoplasm of adrenal medulla
What does Addison's disease, Chuching's syndrome, Conn's syndrome all have in common?
They are diseases of the adrenal glands
What is Addison's disease?
insuffiecnt production of adrenocorticoids
What disease is characterized by insufficeint production of adrenocorticoids?
What is cushing's disease?
Excess corticosteroids, particularly glucocorticoids
What disease is characterized by excess production of corticosteroids, paricularly glucocorticoids (cortisol)?
Conn's disease is:
Overproduction of mineralcorticoids
What disease is characterized by the overproduction of mineralcorticoids (aldosterone)?
What is the main glucocorticoid?
What is the main mineralcorticoid?
What neoplasm of the adrenal medulla is found in children?
What neoplasm of the adrenal medulla is found in adults?
What is characteristic of neuroblastoma and pheochromocytoma?
They both have excess production of catecholamines
If an adult has excess production of catecholamines, what disease is suspect?
If an child has excess production of catecholamines, what disease is suspect?
What causes Addison's disease?
tuberculosis and idiopathic adrenal atrophy
How does Addison's disease manifest itself?
- Increased skin pigment
- Intestinal complaints
- Loss of body hair
- decreased serum corticosteroids
- Increased ACTH
If person presnets with decreased body hair, depression, intestinal upset, increased pigmentation on skin, tiredness, decreased serum corticosteroids and increased ACTH, what would the diagnosis be?
Where do skin pigmentation changes happen in aperson with Addison's disease?
skin folds and pressure points, such as knees, elbows, knuckles, toes, mucous membranes
Acute addison's disease needs what treatment?
- life threatening:
- immediate treatment with glucocorticoids and IV fluids with salt and sugar
What is the treatment for Chronic Addison's disease?
What cushing's syndrome is caused by what four things?
- adrenal cortical tumor
- tumor in anterior pituitary
- lung tumror
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