PTG 105- Exam 3- Lecture 20 - 5

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PTG 105- Exam 3- Lecture 20 - 5
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2013-04-09 22:59:35
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PTG 105 Exam Lecture 20
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PTG 105- Exam 3- Lecture 20 - 5
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  1. What are the lesions associated with Hypothyroidsim?
    • Destruction
    • atrophy
    • fibrosis
    • lymphocystic infiltration
    • connective tissue changes
  2. What is the treatment for Hypothyroidism?
    Thyroid hormone replacement
  3. What is mydexema?
    Swelling of skin and tissues due to accumulation of mucopolysaccharides
  4. What is Cretinism?
    Hypothyroidism in infancy
  5. What is the term for hypothyroidism in infancy?
    Cretinism
  6. What are the manifestations of Cretinism?
    • Distended abdomen
    • Protruded tongue
    • Excessive sleeping
    • lethargic
    • Dwarfism
    • mental retardation
  7. An infant that is suffering from dwarfism, mental retardation, distended abdomne, protruded tongue, lethargy and extensive sleeping likely has what disease?
    Cretinism
  8. What is another name for Hashimoto's thyroiditis?
    Struma lymphomatosa
  9. What is Struma lymphomatosa also called?
    Hashimoto's Disease
  10. What type of disorder is Hashimoto's?
    • AutEnlarged thyrois
    • muscle weakness
    • Increased T4, T3 and I131 uptakes
    • Decreased TSH
  11. A patient that has lost weight has a tremor, emotional instability, muscle weakness, nervousness, rapid HB, enlarged thyroid, Increased T3 and T4 and increasde I131 uptake and decreased TSH likely has:
    Hyperthyroidism
  12. Grave's disease is caused by what?
    • Antibody against TSH receptor
    • Antibody mimics the TSH effect
  13. If a person has an antibody against aTSH receptor that is mimicing TSH stimulation, what disease do they have?
    Grave's Disease
  14. What is a physical manifestation of Grave's disease?
    • Diffuse enlargement of the thyroid gland - Diffuse toxic goiter
    • infiltrative dermopathy and opthalmopathy
    • Exophthalmos
    • Pretinial myxedema
  15. What disease characteristically has a diffuse toxic goiter?
    Grave's disease
  16. What disease has infiltrative dermopathy and ophthalmopathy?
    • Grave's disease
    • oimmune disorder
  17. What happens to the thyroid gland in Hashimoto's thyroiditis?
    Diffuse enlargement
  18. If the thyroid gland show lymphocystic aggregates and well formed germinal centers and follciles are lines by Hurthle cells, what disease is indicated?
    Hashimoto's thyroiditis
  19. What are the histological changes associated with Hashimoto's thyroiditis?
    • Lymphocytic aggregates with well formed germinal centers
    • Follicles lined with Herthle cells
  20. Reidel's thyroiditis is how prominant?
    Rare, mostly femal disease
  21. Describe teh gross morphology of Reidel's thyroiditis:
    Stony hard gland adherent to naighboring tissues
  22. When a stony hard thyroid gland that is adherent to neighboring tissues is found, what disease is indicated?
    Reidel's thyroiditis
  23. What is the pathogenicity of Reidel's thyroiditis?
    Fibrous hyalinized tissue takes over thyroid gland, clinically mimicing carcinoma
  24. When fibrous, hyalinized tissue takes over the thyroid gland, what disease is indicated?
    Reidel's thyroiditis
  25. Reidel's thyroiditis clinically mimics what other disease?
    Carcinoma
  26. How common is Subacute Granulomatous Thyroiditis?
    Less common than Hashimoto's disease
  27. What age group is most susceptible to Subacute Granulaomatous thyroiditis?
    30-50 year olds
  28. What are the manifestations of subacute granulomatous thyroiditis?
    • Thyroid pain, enlargement and fever
    • Hyperthyroidism followed by Hypothyroidism
  29. A person presenting with Hyperthyroidism and then hypothyroidism, painand enlargement in the thyroid and fever, likely has what disease? 
    Subacute Granulomatous Thyroiditis
  30. Describe the early of three stages of Subacute Granulomatous thyroiditis:
    • disruption of follicles
    • PMN response
  31. Describe the later of three stages of Subacute Granulomatous thyroiditis:
    plump macrophages around damaged follicles or colloid pools
  32. Describe the Late of three stages of Subacute Granulomatous thyroiditis:
    Chronic inflammation and fibrosis
  33. What stage of Subacute Granulomatous thyroiditis includes chronic inflammtion nd fibrosis of the thyroid?
    Late stage (stage 3 of 3)
  34. What stage of Subacute Granulomatous thyroiditis includes plump macrophages around damaged follicles and colloid pools?
    Later stage ( middle of 3)
  35. What stage of Subacute Granulomatous thyroiditis includes disruption of the follicles and PMN response
    Early stage (1 of 3)
  36. Hyperthyroidism is caused by what?
    • Grave's disease
    • Toxic nodular goiter
    • thyroid neoplasm
  37. Grave's disease
    Toxic nodular goiter
    thyroid neoplasm can all cause what disease?
    Hyperthyroidism
  38. What lesions are associated with hyperthyroidism?
    • Diffuse hyperplasia
    • Lymphocytic infiltration
    • Hyperplastic nodule
    • Secretory neoplasm
  39. What disease is indicated by Diffuse hyperplasia, lymphocytic infiltration, hyperplastic nodule and Secretary neoplasm?
    Hyperthyroidism
  40. How does hyperthyroidism manifest itself?
    • Tremor
    • Nervousness
    • Emotional instability
    • heat tolerance
    • Rapid HB
    • weight loss

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