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What are the lesions associated with Hypothyroidsim?
- lymphocystic infiltration
- connective tissue changes
What is the treatment for Hypothyroidism?
Thyroid hormone replacement
What is mydexema?
Swelling of skin and tissues due to accumulation of mucopolysaccharides
What is Cretinism?
Hypothyroidism in infancy
What is the term for hypothyroidism in infancy?
What are the manifestations of Cretinism?
- Distended abdomen
- Protruded tongue
- Excessive sleeping
- mental retardation
An infant that is suffering from dwarfism, mental retardation, distended abdomne, protruded tongue, lethargy and extensive sleeping likely has what disease?
What is another name for Hashimoto's thyroiditis?
What is Struma lymphomatosa also called?
What type of disorder is Hashimoto's?
- AutEnlarged thyrois
- muscle weakness
- Increased T4, T3 and I131 uptakes
- Decreased TSH
A patient that has lost weight has a tremor, emotional instability, muscle weakness, nervousness, rapid HB, enlarged thyroid, Increased T3 and T4 and increasde I131 uptake and decreased TSH likely has:
Grave's disease is caused by what?
- Antibody against TSH receptor
- Antibody mimics the TSH effect
If a person has an antibody against aTSH receptor that is mimicing TSH stimulation, what disease do they have?
What is a physical manifestation of Grave's disease?
- Diffuse enlargement of the thyroid gland - Diffuse toxic goiter
- infiltrative dermopathy and opthalmopathy
- Pretinial myxedema
What disease characteristically has a diffuse toxic goiter?
What disease has infiltrative dermopathy and ophthalmopathy?
- Grave's disease
- oimmune disorder
What happens to the thyroid gland in Hashimoto's thyroiditis?
If the thyroid gland show lymphocystic aggregates and well formed germinal centers and follciles are lines by Hurthle cells, what disease is indicated?
What are the histological changes associated with Hashimoto's thyroiditis?
- Lymphocytic aggregates with well formed germinal centers
- Follicles lined with Herthle cells
Reidel's thyroiditis is how prominant?
Rare, mostly femal disease
Describe teh gross morphology of Reidel's thyroiditis:
Stony hard gland adherent to naighboring tissues
When a stony hard thyroid gland that is adherent to neighboring tissues is found, what disease is indicated?
What is the pathogenicity of Reidel's thyroiditis?
Fibrous hyalinized tissue takes over thyroid gland, clinically mimicing carcinoma
When fibrous, hyalinized tissue takes over the thyroid gland, what disease is indicated?
Reidel's thyroiditis clinically mimics what other disease?
How common is Subacute Granulomatous Thyroiditis?
Less common than Hashimoto's disease
What age group is most susceptible to Subacute Granulaomatous thyroiditis?
30-50 year olds
What are the manifestations of subacute granulomatous thyroiditis?
- Thyroid pain, enlargement and fever
- Hyperthyroidism followed by Hypothyroidism
A person presenting with Hyperthyroidism and then hypothyroidism, painand enlargement in the thyroid and fever, likely has what disease?
Subacute Granulomatous Thyroiditis
Describe the early of three stages of Subacute Granulomatous thyroiditis:
- disruption of follicles
- PMN response
Describe the later of three stages of Subacute Granulomatous thyroiditis:
plump macrophages around damaged follicles or colloid pools
Describe the Late of three stages of Subacute Granulomatous thyroiditis:
Chronic inflammation and fibrosis
What stage of Subacute Granulomatous thyroiditis includes chronic inflammtion nd fibrosis of the thyroid?
Late stage (stage 3 of 3)
What stage of Subacute Granulomatous thyroiditis includes plump macrophages around damaged follicles and colloid pools?
Later stage ( middle of 3)
What stage of Subacute Granulomatous thyroiditis includes disruption of the follicles and PMN response
Early stage (1 of 3)
Hyperthyroidism is caused by what?
- Grave's disease
- Toxic nodular goiter
- thyroid neoplasm
Toxic nodular goiter
thyroid neoplasm can all cause what disease?
What lesions are associated with hyperthyroidism?
- Diffuse hyperplasia
- Lymphocytic infiltration
- Hyperplastic nodule
- Secretory neoplasm
What disease is indicated by Diffuse hyperplasia, lymphocytic infiltration, hyperplastic nodule and Secretary neoplasm?
How does hyperthyroidism manifest itself?
- Emotional instability
- heat tolerance
- Rapid HB
- weight loss