PTG 105 -Exam 3 -Lecture 21- 3

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PTG 105 -Exam 3 -Lecture 21- 3
2013-04-10 00:58:34
PTG 105 Exam Lecture 21

PTG 105 -Exam 3 -Lecture 21- 3
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  1. What is Osteosarcoma?
    Malignant tumor that produces bone matrix
  2. What is the new bone called that is produced by the cells of Osteosarcoma?
    Malignant Osteoid
  3. What is the most common primary bone malignancy?
  4. How does the primary form of Osteosarcoma arise?
    de novo
  5. How does the secondary form of Osteosarcoma arise?
    As a complication of another condition such as Paget's disease or radiation
  6. How does osteosarcoma manifest itsel?
    painful bone mass or fracture
  7. What percent of osteosarcoma sufferers have pulmonay metastases?
  8. What is the longe term survival rate for Osteosarcoma?
  9. What are common physical traits of Osteosarcoma?
    • Lifts peristeum- called Codman triangle
    • Lytic and blastic mass that breaks through cortex
  10. Osteosarcoma is most common in what age group?
  11. Osteosarcoma is most common in what body locations?
    Distal femur and proximal tibia
  12. What is Chondroma?
    Benign tumor or hyaline cartilage
  13. What is a Benign tumor or hyaline cartilage?
  14. Osteochondroma is what?
    benign cartilage capped outgrowth (exostosis)
  15. What are the main bones involved in Osteochondroma?
    Long bones of extremities
  16. Chondrosarcoma is what?
    Malignant cartilage forming tumors (produce nepplastic cartilage)
  17. What parts of the skeleton are most commonly involved in Chondrosarcoma?
    • Central/Axial skeleton
    • Shoulders, pelvis, ribs, etc.
  18. What is the second most common malignanat tumor of bone?
  19. What is the most common malignant tumor of bone?
  20. What are th physical manifestations of Chondrosarcoma?
    • Painful expansilemass
    • fracture
  21. What group is more susceptible to Chondrosarcoma?
    • Males: Females = 2:1
    • Older than fourty years
  22. Where do Chondrosarcoma metastisize to?
    Lungs and skeleton
  23. What visually is differnt about bone of Chondrosarcoma?
    Nodules of grey-white glistening tissue
  24. If you see nodules of grey white glistening tissue in bone, what would be suspect?
  25. What is Giant Cell Tumor?
    Benign but locally aggressive tumor of proliferating osteoclasts
  26. What is the term for a benign but locally aggresive tumor of proliferating osteoclasts?
    Giant cell tumor
  27. What type of cell is most significant in Giant cell tumors?
    large numebr of osteoclast giant cells
  28. What proportion of all benign bone tumors are giant cell tumors?
  29. What age group is affected by giant cell tumors?
    20-40 years
  30. What areas are Giant cell tumors found?
    • knee
    • distal femur
    • proximal tibia
  31. What are signs of giant cell tumor?
    • Pain
    • fractures
  32. What is the treatment for giant cell tumors?
  33. What often happens after treatment of Giant cell tumors by cutterage?
  34. What is Ewing sarcoma?
    Highly malignant small round blue cell tumor
  35. What disease is of a small round blue cell tumor that is very malignant?
    Ewing Sarcoma
  36. What sex more commonly gets Ewing Sarcoma?
  37. When in life does Ewing sarcoma occur?
    10-15 years, peaks in 20s
  38. What is the second most common bone tumor in children?
    Ewing sarcoma
  39. What is the orgin of Ewing sarcoma?
    neural orgin, exhibits neural pheotype on histology
  40. WHat is the chromosomal location fo Ewing Sarcoma?
    t11:22 transolaction
  41. What are the symptoms of Ewing sarcoma?
    Painful mass and fever
  42. What is the survival rate for ewing sarcoma?
    75% in 5 years
  43. What bones are commonly affected in Ewing Sarcoma?
    long tubular bones and flat bones of the pelvis
  44. MIC2 indicates what?
    It is a marker for neural orgin