PTG 105 -Exam 3 -Lecture 21- 2
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What is the cause of Rickets/Osteomalacia
Poor intake or utilization of Vit. D
What is caused by poor intake or utilization of Vit. D?
Osteomalacia or Rickets
What serum levels can be used to detect Rickets/OM?
Low serum phosphate and Ca levels
What are signs of Rickets?
- Soft spot on head is slow to close
- bony necklace
- bowed legs
- big lumpy joints
- curved bones
A child that presents with big lumpy joints, curved bones, bowed legs, a slow closing soft spot on the head and a bony necklace is likely to have what disease?
Osteomyelitis is what?
Infection of the bone
What is the term for infection of the bone?
What are common causes of Osteomyelitis?
- commonly caused b ypyogenic bacteria like Staph
- Mycobacteria (TB)
What are the two main types of Osteomyelitis?
- Hematogenous route
- Secondary OM
Describe the pathology of Hematogenous Osteomyelitis:
- Sprad through blood and localizes on bone
- causes pus formation
- causes bone necrosis
What are the symptoms of Hematogenous Osteomyelitis?
Bone pain and swelling
Where is the usual site of entry for Hematogenous Osteomyelitis?
What is the usual infecting bacteria in Hematogenous Osteomyelitis?
Describe Secondary Osteomyelits:
infection spread to bone from adjacent site of infection or open wound
When an infection spread to the bone through an adjacent site or wound, what is it called?
Describe Acute Osteomyelitis:
- Intense neutrophilic inflammation
- abcess formation
- drainage of sinuses
- bone necrosis
Describe Chronic Osteomyelitis:
- chronic inflammatory cells initiate repair process
- fibroblastic proliferation
- residual necrotic bone is called sequestrum
Which pathological type fo OM contains sequestrum?
Which pathological type of OM has intense neutorphilic inflammation, abcess formation, draining sinuses and necrotic bone?
Which type of OM has inflammatory cell intiate repair, fibroblastic proliferation, residual necrotic bone is called sequestrum?
What is Pott disease?
Tuberculosis OM of vertebra
What is the term for Tuberculosis Om of the vertebra?
Describe Pagets disease:
Skeletal deformity due to accumulation of excess amount of architectually abnormal bone
What disease is a skeletal deformity where exess amounts of abnormal bine accumulate?
PAget's disease etiology is:
- possibly viral (paramyxomius)
Paget's disease is common in what races and rare in what others?
- Common in northern european whites
- Rare in Asia or Africa
What disease has the charcteristic f Mosaic patterns of lamellular bone?
Paget's disease has what characteristic bone pattern?
Mosaic pattern of lamellular bone
Paget's disease is associated with an increaed risk of what other disease?
Osteosarcoma (malignant bone tumor)
What is another term for malignant bone tumor?
What is the pathogenic effect sof paget's disease?
marked by bone reabsorption, followed by excessive bone formation
What is another name for Paget's disease?
What bones are commonly affected by Paget's disease?
Skull, spine, Pelvis, thigh and shin
What is an osteoma?
Benign bone tumor
Where are Osteomas usally found?
mature bones, commonly in head or neck
Osteoid Osteoma (Osteoblastoma) is what?
Benign tumor of the bone (usually femur)
What is the differnce between an Osteoid Osteoma and and Osteoblastoma?
An Osteoblatoma is greater than 2 cm ad a Osteoid Osteoma is less than 2cm in diamter
What is the occurance of Osteoid Ostoma or Osteoblastoma between men and women?
What bones are involved in Osteiod Osteoma and Osteoblastoma?
Any bone, 50% are the femur
What age group commonly gets Osteoid Ostoma?
20s to 30s
Histologically what do Osteoid Osteoma look like?
Resemble normal bone
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