Lab Final - Capsules

Home > Flashcards > Print Preview

The flashcards below were created by user jcu1 on FreezingBlue Flashcards. What would you like to do?

  1. two types of capsules
    hard gelatin and soft gelatin
  2. ingredients in a capsule vs tablet
    drug, diluent, lubricant

    tablet also needs binders, disintegrants, glidants, coloring agents, etc
  3. disadvantages of capsules
    • possiblity of tampering
    • limited capsule shell suppliers
    • not good for highly soluble salts
    • not good for hygroscopic, deliquescent drugs
    • not good for efflorescent drugs
    • not good for drugs/excipients that solubilize gelatin
  4. hard gelatin capsule shell composition
    • gelatin
    • preservative
    • water
    • sugar
    • opaquing agent
    • colorant
  5. soft gelatin capsule shell composition
    • gelatin
    • preservative
    • water
    • opaquing agent
    • sugar
    • colorant
    • PLUS glycerin/PG
  6. manufacturing of hard vs soft capsules
    • hard: two steps (making of capsule shell and filling)
    • soft: produced, filled, and sealed in one operation
  7. how is the gelatin made
    animal bone, skin, or collagen hydrolyzed into type A or B gelatin

    • typeA: plasticity
    • typeB: firmness
  8. capsule size range
    • smaller number = bigger capsule
    • bigger number = smaller capsule
  9. excipients used in capsule development
    • diluent/filler: produces proper fill volume
    • disintegrant: breakup capsule contents in the stomach
    • lubricant: lowers friction btween powder and metal surfaces of filling machines
    • glidant: improve powder flow
  10. examples of capsule diluents/fillers
    • lactose
    • microcrystalline cellulose
    • dicalcium phosphate
  11. examples of capsule disintegrants
    • pregelatinized starch
    • sodium starch glycolate
    • crospovidone
  12. examples of capsule lubricants
    magnesium stearate
  13. examples of capsule glidants
  14. bulk density
    weight of powder in graduated cylinder/volume occupied by powder
  15. tap density
    weight of powder in graduated cylinder/volume occupied by powder after 200 taps
  16. compressibility of powder mix/% compressibility
    (1 - bulk density/tap density) x 100
  17. rule of seven
    • 1. convert weight of powder+capsule into grains
    • 1 grain = 0.065 grams
    • 2. subtract number from 7
    • 3. compare to the table to choose capsule size

Card Set Information

Lab Final - Capsules
2013-04-10 12:45:57
Lab Final

Lab Final
Show Answers:

What would you like to do?

Home > Flashcards > Print Preview