What are the two causes of type II diabetes?
Not really clear on what causes
1. Decreased responsiveness of target cells to insulin. May be due to genetic defect of insulin or insulin receptor or target cells may supress the activity of a response pathway. Obesity may play a role in this. Obesity causes adipose tissue to not receive enough blood. This leads to death of adipose tissue, which leads to an immune response, which leads to decreased response to insulin in certain target cells, such as cells in the liver, adipose tissue, and muscle.
2. Steady decline in production of insulin. There are a number of different causes. One might be that there is an increased rate of apoptosis in the beta cells. Another is that Beta cells might become dedifferentiated under conditions of physiological stress.