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pharma II test 3, vasoactive peptides
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structural feature of ang I and ang II
ang I is a decapeptide
ang II is an octapeptide
natriuretic peptide
ANP increases Na secretion and urine flow, GFR increases,
vasodilation
, decrease BP(cGMP)
vasoactive intestinal peptide (VIP)
marked vasodilation independent of NE, ACh, serotonin and histamine receptros
substance P
potent vasodilator, contraction of venous, intestinal and bronchial SM
neurotensin
peripheral vasodilator
calcitonin gene-related peptide (CGRP)
presents in large quantity in the C cells of the
thyroid gland
peripherally
: hypotension and tachycardia -
most potent vasodilator so far
CNS - suppression of feeding
neuropeptide Y (NPY)
functions both as a vasoconstrictor and a cotransmitter with norepinephrine
CNS
: increased feeding
peripheral
: vasoconstriction
antagonist of neuropeptide
PP56
which step does ACE inhibitors work on
ang I - ang II
if a patient with HTN has a night cough complaint which vasoactive drug should be avoided
ACEI
NOS inhibitor
l-NMMA
NOS scavenger
hemoglobin
inducible isoform of NO
iNOS - located in the macrophages of smooth muscle cells
isoforms of NO that require Ca
nNOS - located in the neuronal & epithelial cells
eNOS - located in the endothelial cells
substrate for NO
L-arginine
indicator of NO since it has a short half life
L-citrulline
activated by NO and the response
NO activates guanylyl cyclase (GC) bound by phosphate and GTP producing increase in cGMP causing myosin relaxation
vasodilation
platelet inhibition
smooth muscle regulation
immune regulation
serves as a reservoir for NO
glutathione
beneficial oxides of nitrogen
nitrite
nitrate
2 signaling pathways useful in practice for NO(I)
neurons in the brain
macrophage
2signaling pathways useful in practice for NO (II)
dilating blood vessels for erection of the penis
inhaled for newborn high blood pressure in the lungs
NO septic shock cause and TX
increased urinary excretion of nitrates
Tx - methy blue (GC inhibitor)
hemoglogin (NO scavenger)
NO use in atherosclerosis
antioxidant blocking the oxidation of LDL preventing the formation of foam cells in vascular wall (macrophage engulfs)
excessive NO
detrimental during acute organ rejection due to up-regulation of iNOS by cytokines
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pharma II test 3, vasoactive peptides
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pharma II test 3, vasoactive peptides
Updated
4/10/2013, 11:56:47 PM
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