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Striant (4)
- Actient
- Buccal System
- replace every 12 hours
- 30 mg/daily
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Androderm
- Patch
- qd
- Watson
- 2mg applied to back, abdomen, upper arms, thighs (rotated)
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Depo-Testosterone
- Pharmacia
- 50-400mg every 2-4 weeks
- Injection (buttocks)
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Delatestryl
- Indevus
- 50-400mg every 2 weeks
- injection
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Testim 1%
- Auxillum
- Gel
- 5-10 mg/day
- applied to shoulders and upper arms
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Axiron 2%
- Lilly
- underarm applicator
- 30-120 mg/day
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Negatives of oral TRT (2)
- Quickly broken down by liver and does not achieve high enough blood levels to be useful unless in large doses
- large doses can cause adverse changes in lipids and cause liver damage
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Andriol
- Organon
- 80-160 mg/day
- tablet
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Ideal TRT
produces and maintains physiolgic serum levels of testosterone without side effects or safety concerns
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Azoospermia (2)
- Administration of exogenous Testosterone as a means of male contraception under study
- usually results within approx 10 weeks of beginning therapy
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Lipid Abnormalities (3)
- TRT is known to reduce total cholesterol
- LDL and HDL
- Lipid values should be followed closely in men receiving TRT
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Polycthemia (3)
- high red blood cell count
- has been associated with TRT
- correlated with elevated bioavailable Testosterone and estradiol levels
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PSA (4)
- prostate specific antigen
- levels of 4-10 are concerning
- identifies prostate cancer risk
- for patients 50 and older
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Prostate Cancer and TRT (2)
- little to no association between TRT and development of prostate cancer
- recent studies indicate that Testosterone levels have no apparent systematic relationship to prostate cancer
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Hematocrit (2)
- volume % of red blood cells in blood
- normal for men is 45%
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Fortesta 2%
- Gel
- Applied to inner and/or upper thighs
- Endo Pharma
- 10-70 mg/day
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Androgel 1% and 1.62% (5)
- Gel
- Abbott
- 1% 5-10g/day
- 1.62 % 20.25 - 81 mg a day
- apply to shoulders and upper arms (abdomen 1% only)
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Why should TRT be given to boys/Men?
- stimulate puberty in boys
- increase testosterone production in men
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T or F - TRT cause a decrease in sperm production?
True
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Types of TRT (6)
- Pellets
- Gel
- buccal system
- oral
- patch
- injection
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Testopel (5)
- 75 mg
- rice sized pellet
- implanted in outer quadrant of hip via trocar
- placed in subermal fat 3-4 inches below belt line
- lasts 3-6 months (only FDA approved)
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Problem with compounded products (2)
- No quality control
- inconsistent production
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Standard TRT monitoring (3)
- Once every 3-6 months for a year
- Every 12 months after that
- assess clinical response, blood tests
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Contraindications of TRT (3)
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- Men with breast cancer
- Men with prostate cancer
- Pregnant Women
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