Card Set Information
Antiepileptic drugs, Antipsychotic drugs, Anxiolytics/Hypnotics, Antidepressant drugs
What are the types of seizures?
: Simple partial, Complex partial
: Absence, Generalized Tonic-Clonic, Status Epilepticus
What type of seizure is Phenytoin used for?
Generalized and Partial
What is Phenytoin MOA?
Sodium channels inhibition.
How long may it take to reach a steady level for Phenytoin?
~5-7 days, may be up to 14 days
What are the adverse effects of Phenytoin?
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Ataxia, dizziness, diplopia, sedation, nystagmus, nausea, vomiting, impaired motor control, liver enzymes.
True or false: Serum level of Phenytoin should be corrected with albumin level.
What is the therapeutic range for Phenytoin?
Why does Phenytoin have a non-linear pharmacokinetic?
If liver enzymes are overwhelmed, plasma levels of the drug increases disproportionately.
What is Carbamazepine (Tegretol) used for?
To prevent partial and generalized seizures, BPAD and pain.
What is the MOA of Carbamazepine (Tegretol)?
Voltage-dependent sodium channels inhibition.
Onset for Carbamazepine (Tegretol)?
Steady state for Carbamazepine (Tegretol)?
Therapeutic range for Carbamazepine (Tegretol)
Adverse effect of Carbamazepine (Tegretol)
NVD ADD N LT SJS PP R
Nausea, vomiting, diarrhea, ataxia, dizziness, diplopia, nystagmus, leukopenia, thrombocytopenia, SJS, pruritis, photosensitivity, rash.
What are the uses for Valporic Acid (Depakene)/ Divalporex (Epival)?
Broad spectrum antidepressant, BPAD, migranes
Valporic Acid (Depakene)/ Divalporex (Epival)
Enhances GABA-mediated inhibition
Valporic Acid (Depakene)/ Divalporex (Epival) steady state?
Valporic Acid (Depakene)/ Divalporex (Epival) therapeutic range?
Valporic Acid (Depakene)/ Divalporex (Epival)
STT? NV W H
Sedation, tremor, thrombocytopenia, nausea, vomiting, weight gain, hair loss.
Ethosuximide (Zarontin) uses?
Ethosuximide (Zarontin) MOA
calcium channels inhibition
Ethosuximide (Zarontin) adverse effects
NV S R NIGHT
NeVer Sleep RASHionally at NIGHT
Nausea, vomiting, sedation, rash, nightmares.
Lamotrigine (Lamictal) uses:
partial seizure, adjunct in generalized seizure
Lamotrigine (Lamictal) MOA
sodium channels inhibition
Lamotrigine (Lamictal) side effects
CNS SE common
Topiramate (Topimax) use
adjunctive therapy for partial seizures
Topiramate (Topimax) MOA
multiple: blocks voltage-dependent sodium channels, enhances GABA activity
Topiramate (Topimax) SE
Kidney stones impair your weight
impaired cognition, weight loss, kidney stones
Oxcarbazepine (trileptal) use
Partial and secondary GTC (Generalized Tonic-Clonic)
Oxcarbazepine (trileptal) MOA
Oxcarbazepine (trileptal) se
Levetiracetam (Keppra) use
Levetiracetam (Keppra) MOA
Levetiracetam (Keppra) elimination
Levetiracetam (Keppra) drug interaction
Lacosamide (Vimpat) use
adjunct in partial seizure
Lacosamide (Vimpat) MOA
sodium channel slow activation
generalized and partial seizure as well as refractory status epilepticus.
binds to GABA receptor
Hang over effect
T or F: Patients on Phenobarbital can develop a tolerance/dependence
enhances GABA mediated inhibition
Benzodiazepines common agents
clobazam, diazepam, lorazepam, clonazepam.
name 2 Benzodiazepines that are use in status epilepticus and are able to cross the BBB when given parenterally
lorazepam and diazepam
what are positive symptoms?
things that are considered extra. aggression, lack of sleep, etc...
can be treated within a day or two.
the new antipsychotic drugs associated with lower rates of ______ but higher rates of ___ ___
EPS; weight gain
what are the target symptoms of antipsychotics?
combativeness, hallucinations, delusions, insight.
what are antipsychotics used for?
psychotic disorders, schizophrenia, mania, delirium, adjunct in alzheimer's.
what are the target receptors of antipsychotics?
D2, muscarinic, alpha-1 recptors, histamine, 5ht2 receptors.
Olanzapine (Zeprexa) is used for
Mania, schizophrenia, BPAD
Available forms of Olanzapine (Zeprexa)
oral tabs, RDT, IM inj
Uses for Quetiapine (Seroquel)
Mania, schizophrenia, BPAD, delirium, dementia, agitation, anxiety
forms of Quetiapine (Seroquel)
oral tabs (immediate and xr)
which Antipsychotic has the least EPS
Uses for Risperidone (Risperdal)
schizophrenia, BPAD, delirium, dementia, agitation.
forms of Risperidone (Risperdal)
oral (tabs, M-tab, liquid) depot inj
which antiphyschotic has the highest risk for eps?
Ziprasidone (Zeldox) uses
schizophrenia, BPAD, agitation
Ziprasidone (Zeldox) forms
Clozapine (Clorazil) biggest important SE
what is NMS?
life threatening reaction associated with use of antipsychotics. symptoms are: muscle rigidity, hypertermia, autonomic dysfunction, altered consciousness. treat with anticholinergic agents.
T or F: Overdose is not too much of a concern with benzodiazepines.