PCM II CANCER

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Author:
islandgirljane
ID:
212907
Filename:
PCM II CANCER
Updated:
2013-04-11 14:59:08
Tags:
CANCER DRUGS
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Description:
Cancer Medications
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  1. Fluorouracil (antimetabolite)
    5-FU
  2. Cytoxan (alkylating agents)
    NITROGEN MUSTARD
    cyclophosphamide
  3. Leukeran (alkylating agents)
    NITROGEN MUSTARD
    chlorambucil
  4. methotrexate
    MTX
  5. Casodex
    bicalutamide
  6. List Nonsteroidal antiandrogens
    • Casodex (bicalutamide)
    • Eulexin (flutamide)
  7. Lupron
    leuprolide
  8. Arimidex
    anastrozole
  9. Megace
    megesterol
  10. Imuran
    azathioprine
  11. Purinethol
    6-MP
  12. CellCept
    mycophenolate MMF
  13. Leucovorin calcium
    Folinic acid
  14. How does 5-FU work
    • -metabolized via anabolic pathway--> blocks methylation rxn of dUMP to dTMP
    • -interferes w/synthesis of DNA, inhibits formation of RNA
    • -creates a thymidylate deficiency
  15. What is the counseling for 5-FU?
    • avoid SUN - blisters
    • avoid eyes - blindness
    • wash hands
  16. How does cytoxan work?
    • the activated form phosphoramide mustard, alkylates binds w/intracellular molecular structures
    • Cross-links DNA and RNA strands
  17. Dosage for for 5-FU
    • Carac Cream 0.5% -QD X 3 days
    • Fluroplex 1% Cream BID X 14 days
    • Efudex 5 % Cream BID X 14 days
  18. Dose for cytoxan
    25, 50 mg TABS  

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