Transfusion reaction

Card Set Information

Author:
ucstudent01
ID:
212966
Filename:
Transfusion reaction
Updated:
2013-04-11 19:37:21
Tags:
Transfusion reactions
Folders:

Description:
Transfusion Reactions
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user ucstudent01 on FreezingBlue Flashcards. What would you like to do?


  1. Febrile nonhemolytic / ATR 

    Etiology
    Recipient antibodies to donor WBC

    • Cytokines accumulated
    • during storage
  2. Febrile nonhemolytic - ATR

    Symptoms
    • Fever (>1C or 2F) with or without chills. (Can occur at
    • beginning or 1—2 hrs after transfusion.

    Nausea/vomiting

    HTN

    Tachycardia or Tachypnea
  3. Febrile nonhemolytic - ATR

    Treatment
    1.     Discontinue transfusion

    2.     Report reaction

    • Symptomatic treatment or
    • none
  4. Allergic / ATR

    Symptoms
    • Uticaria, hives, itching, nausea, coughing, wheezing, respiratory
    • distress, diarrhea, or vascular instability.
  5. Allergic/ ATR

    Etiology
    • 1.     Recipient antibody to plasma proteins – increased amount of
    • units given.

    Possible IgA deficiency
  6. Allergic / ATR

    Treatment.
    For mild case:

    - Interrupt transfusion,

    - Administer antihistamines,

    - May continue transfusion.

    • More severe cases: may
    • require corticosteroids
  7. Transfusion related Acute Lung Injury (TRALI)
    ATR

    Symptoms
    1.     Acute respiratory distress:

    •      a: dyspnea, &
    • fever

    •      b: Bilateral
    • pulmonary edema

    •      c: Cyanosis &
    • severe hypoxemia (pO2 30-50 mm Hg & O2 <90%

    •      2:  
    • Hypotension (unresponsive to fluid admin.)
  8. Transfusion Related Acute Lung Injury (TRALI)
    ATR

    Etiology
    1: Donor HLA or neutrophil ABS

    •       2: Two stage injury: Primed neutrophils
    • secondary to lung trauma or infection then transfusion of biologically active
    • lipids
  9. Transfusion Related Acute Lung Injury (TRALI)
    ATR

    Treatment
    1.     Stop Transfusion

    • 2.     Supportive therapy may be necessary: Intubation, O2,
    • or Mechanical ventilation.

    • Improves within 48-96
    • hours.
  10. Transfusion Associated Sepsis
    ATR

    Symptoms
    • 1.     Fever >3C above baseline
    • 2.     Chills
    • 3.     Tachycardia
    • 4.     Hypotension
    • 5.     Nausea/vomiting
    • 6.     SOB
    • Back Pain
  11. Transfusion Associated Sepsis
    ATR

    Etiology
    Bacterial contamination
  12. Transfusion Associated Sepsis
    ATR

    Treatment
    1.     Stop Transfusion

    2.     Send units to lab

    • A: Examine for discoloration, bubbles, plt clumping, culture
    • & gram stain sample form unit.

    • 3.     Blood Cultures from pt. (cultures from unit and pt. should both
    • have organism.)

    • Supportive pt care (may
    • need antibiotics.
  13. Transfusion Associated Circulatory Overload (TACO)
    ATR

    Symptoms
    • 1.     Respiratory distress
    • 2.     Hypoxemia
    • 3.     Headache
    • 4.     Cough
    • 5.     Chest tightness
    • 6.     HTN
    • 7.     Jugular vein distension
    • 8.     Increased Central venous pressure 
    • 9.     Increased pulmonary wedge
    • pressure.
  14. Transfusion Associated Circulatory Overload (TACO)
    ATR

    Etiology
    • The patient’s cardiovascular system cannot handle the additional
    • workload, therefore causing CHF.
  15. Transfusion Associated Circulatory Overload (TACO)
    ATR

    Treatment
    • 1.     Stop transfusion
    • 2.     Treat for CHF
    • 3.     Lab Test: BNP is increased
    • 4.     Put patient in Upright posture
    • 5.     Give O2
    • Diuresis
  16. Transfusion Associated Graft vs. Host Disease
    DTR

    Symptoms
    • 1.     Rash
    • 2.     Fever
    • 3.     Diarrhea
  17. Transfusion Associated Graft vs. Host Disease
    DTR

    Etiology
    • 1.     HLA antigen difference between donor and recipient
    • 2.     Presence of donor immunocompetent cells in recipient
    • 3.     Recipient incapable of
    • rejecting the blood component
  18. Transfusion Associated Graft vs. Host Disease
    DTR

    Treatment
    1.     No Treatment Available. Patient mortality is high.

    • Preventions: is to provide
    • gamma irradiation products, crossmatch platelets and granulocytes, HLA match

What would you like to do?

Home > Flashcards > Print Preview