Biochemistry

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Author:
Anonymous
ID:
212987
Filename:
Biochemistry
Updated:
2013-04-11 21:28:48
Tags:
fat soluble vitamins
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Description:
fat soluble vitamins
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  1.  Which form of   Vitamin D is present in the skin?
    7-dehydrocholesterol  that is converted to cholecalciferol (vitamin D3) -   by UV light. 
  2. Which form of vitamin D is found in dietary source?
    Cholecalciferol (vit D3) 
  3. What is the role of  liver and kidney in vitamin D metabolism?
    There is two successive hydroxylation of cholecalciferol  in liver and kidney.  Vitamin D3 is converted into  25-hydroxycholecalciferol  by 25-hydroxylase in the liver.  25-hydroxycholecalciferol is converted into 1,25- dihydroxycholecalciferol by 1α-hydroxylase in the kidney. 
  4. Which form of the calcium is  active ?
    1,25-dihydroxycholecalciferol
  5. What is the difference in function of   PTH  and vitamin?
    • Parathormone  decreases the level of phosphate  (parathormone pees phosphate) 
    • Vitamin D increases the level of phosphate  (these both hormones   work together to increase the calcium level , so our only target is to increase calcium level , but, there should  be no effect on phosphate level, so  to make the normal level, one hormone should increase the  phosphate and one hormone should decrease the  phosphate level,
  6. Where is the PTH receptor in the gut located?
    PTH  receptor is absent in  the the gut, so it has to take the help of vitamin D for its action,  So,  it induces  the 1α-hydroxylase for its  action,  This 1,25-DHCC increases the absorption of  calcium form gut.

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