MIC 541-Exam 4- Antimicrobials IV-5

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MIC 541-Exam 4- Antimicrobials IV-5
2013-04-14 17:50:37
MIC 541 Exam Antimicrobials IV

MIC 541-Exam 4- Antimicrobials IV-5
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  1. What Cephalosporins are parenteral?
    • Cefazolin
    • Cephradine
  2. WHat are 1st generation cephalosporins active against?
    • Staphylococcus
    • Streptococcus
    • Not enterococci
    • Some gram - (e.coli, k. pneumoniae, P. mirabilis)
    • Penicillin susceptible anaerobes
  3. What are 1st generation cephalosporins used for?
    • staph or sprep skin/soft tissue infections
    • Steptococcal pneumonia
  4. What are 1st generation cephalosporins are never used for what?
    • Hostpital infections
    • meningitis
  5. What group of cephalosporins should never be used for nosocomial infections or meningitis?
    1st generation
  6. What are 1st generation cephalosporins used for surgical prophylaxis?
    • Cheap
    • Long half life=one dose can cover a good period
  7. What generation of cephalosporins is used for strep or staph skin and soft tissue infections?
    1st generation
  8. Cefazolin is the go to drug for what?
    Surgical prophylaxis
  9. What is the go to drug for surgical prophylaxis?
  10. Name three cephamycins:
    • Cefoxitin
    • Cefotetan
    • Cefmetazole
  11. What is the route of administration for Cefuroxime?
  12. What is the actvity/spectrum for 2nd generation cephalosporins?
    • Similar to 1st generation with greater gram - coverage
    • Active against these gram -:
    • H. influenzae
    • M. morganii
    • Citrobacter
    • Shigella
    • Salmonella
    • Enterobacter
    • Serratia
  13. What cephems are active against B. fragilis?
  14. What are 2nd generation cephalosporins used for?
    • Respiritory tract infections
    • Skin and urine infections
  15. Waht route of administration is availbale for treating Repiritory tract infections and Skin or UTI infections wi th 2nd generation cephalosporins?
  16. 2nd generation cephalosporins are used rarely (T/F)?
  17. Why are 2nd gen cephalosporins used infrequently?
    3rd and 4th generation cephalosporins are better
  18. Ceftazidine is given by what route of administrations?
  19. Oral 3rd generation cephalosporins are not used because they have no activity against what?
  20. What is the spectrum of activity of 2nd generation cephalosporins?
    • Increased gram-negative coverage to P. auruginosa
    • Anaerobes are similar to 1st generation
  21. Ceftazidime is less active against what type of bacteria compared to other 3rd generation drugs?
    Gram positives
  22. What are the main uses for 3rd generation cephalosporins?
    • Nosocomial
    • Meningitis-cross the blood brain barrier
  23. What should have been reserved for Meningitis in penicillin allergic patients?
    33rd generation cephalosporins
  24. Ceftazidime is commonly used against what?
    Community acquired RTIs
  25. Resistance has emerged to what cephalosporins?
    3rd generation
  26. What type of resistance has emerged to 3rd generation cephalosporins?
    in Bacteria that produce AMC-beta-lactamase
  27. 3rd generation cephalosporins cross the blood brain barrier (T/F)?
  28. Why are 3rd generation cephalosporins so good at treating meningitis?
    They cross the blood brain barrier very well
  29. What typw of ion is a 4thgeneration cephalosporin?
  30. What generation of cephalosporins are zwitterions?
    4th generation