MIC 541-Exam 4- Antimicrobials IV-5
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What Cephalosporins are parenteral?
WHat are 1st generation cephalosporins active against?
- Not enterococci
- Some gram - (e.coli, k. pneumoniae, P. mirabilis)
- Penicillin susceptible anaerobes
What are 1st generation cephalosporins used for?
- staph or sprep skin/soft tissue infections
- Steptococcal pneumonia
What are 1st generation cephalosporins are never used for what?
- Hostpital infections
What group of cephalosporins should never be used for nosocomial infections or meningitis?
What are 1st generation cephalosporins used for surgical prophylaxis?
- Long half life=one dose can cover a good period
What generation of cephalosporins is used for strep or staph skin and soft tissue infections?
Cefazolin is the go to drug for what?
What is the go to drug for surgical prophylaxis?
Name three cephamycins:
What is the route of administration for Cefuroxime?
What is the actvity/spectrum for 2nd generation cephalosporins?
- Similar to 1st generation with greater gram - coverage
- Active against these gram -:
- H. influenzae
- M. morganii
What cephems are active against B. fragilis?
What are 2nd generation cephalosporins used for?
- Respiritory tract infections
- Skin and urine infections
Waht route of administration is availbale for treating Repiritory tract infections and Skin or UTI infections wi th 2nd generation cephalosporins?
2nd generation cephalosporins are used rarely (T/F)?
Why are 2nd gen cephalosporins used infrequently?
3rd and 4th generation cephalosporins are better
Ceftazidine is given by what route of administrations?
Oral 3rd generation cephalosporins are not used because they have no activity against what?
What is the spectrum of activity of 2nd generation cephalosporins?
- Increased gram-negative coverage to P. auruginosa
- Anaerobes are similar to 1st generation
Ceftazidime is less active against what type of bacteria compared to other 3rd generation drugs?
What are the main uses for 3rd generation cephalosporins?
- Meningitis-cross the blood brain barrier
What should have been reserved for Meningitis in penicillin allergic patients?
33rd generation cephalosporins
Ceftazidime is commonly used against what?
Community acquired RTIs
Resistance has emerged to what cephalosporins?
What type of resistance has emerged to 3rd generation cephalosporins?
in Bacteria that produce AMC-beta-lactamase
3rd generation cephalosporins cross the blood brain barrier (T/F)?
Why are 3rd generation cephalosporins so good at treating meningitis?
They cross the blood brain barrier very well
What typw of ion is a 4thgeneration cephalosporin?
What generation of cephalosporins are zwitterions?
What would you like to do?
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