MIC 541-Exam 4- Antimicrobials IV-6

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  1. What type of ion is Cefepime?
  2. What is the net negative charge of bacterial cells?
    Net negative charge
  3. 3rd generation cephalosporins have what type of charge?
  4. Why do 3rd generation cephalosporins penetrate bacterial cells slowly?
    • They have a net negative charge, as do bacteria
    • So they are repelled
  5. Why is it important that 4th generation cephalosporins are zwitterions?
    They can penetrate the cell more rapidly than negatively charged molecules (like 3rd gen cephalosporins)
  6. Why is Cefepime more effective than 3rd generation cephalosporins?
    • Faster cell entry
    • targets more PBPs
    • Increased stability in the presence of AmpC B-lactamses
    • Active against AmpC mutants (enterbacter)
  7. What type cephalosporin would be useful against enterobacter?
  8. What cephalosporin has stability with AmpCB-lactamases?
  9. Ceftaroline is the only B-lactam that is active against what?
  10. What B-lactam would you use for an MRSA infection?
  11. Why is Cefteroline important?
    It is active against MRSA
  12. What two bacterial groups does ceftaroline have no activity agains?
    • P. aeruginosa
    • Acinebacter
  13. Can you use Ceftaroline to treat P. Aeruginosa?
  14. Other than MRSA, what penicillin resistant bacteria is Ceftaroline active against?
    Penicillin-resistant streptococcus pneumoniae
  15. What type of administration are available for Cefteroline?
    IM and IV
  16. What is the Anti-MRSA-cephalosporin?
  17. Except for with meningitis what is the preferable cephalosporins to use?
    1st generation
  18. 1st generation cephalosporins are preferable for most situations, except what?
  19. What is the preferred drug for prophylaxis?
  20. What are the adverse reactions of cephalosporins?
    • Cross allergy with Penicillin
    • Bleeding potential (with some)
    • Disulfiram reactions
    • Rashes
  21. Why is there a bleeding potential with some cephalosporins?
    prothrombin interference due to NMTT side chain
  22. How can you prevent or reverse bleeding potential with cephalosporins?
    Vitamin K
  23. Vitamin K is administered in patients on cephalosporins for what purpose?
    To prevent or reverse bleeding issues
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MIC 541-Exam 4- Antimicrobials IV-6

MIC 541-Exam 4- Antimicrobials IV-6
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