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MIC 541-Exam 4- Antimicrobials V-4
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MRSA became completely resistant by gaining what?
van genes
There is a strain of Enterococcus in Michigan that is able to do what?
Transfer van genes to MRSA
What is red man syndrome?
Vancomycin toxicity
What types of Vancomycin adversities exist?
Nephrotoxic
Ototoxic
Red man syndrome
Cardiac effects
rashes
phlebitis
neutropenia
What can cause neutropenia, phlebitis, red man syndrome, cardiac issues, nephrotoxicity, ototoxicity and skin rashes?
Vancomycin
What is red man syndrome due to?
histamine effect
What ways can you reduce red man syndrome from vancomycin?
Slow IV infusion
Slow IV infusion can reduce what Vancomycin adversities?
Red Man syndrome
Nephrotoxicity of vancomycin can be reduced by doing what?
Continuous infusions
Continuous infusions of vancomycin can reduce what adverse effect?
Nephrotoxicity
Telavancin is related to Vancomycin how?
Synthetic derivative
What is a synthetic derivative of Vancomycin?
Telavancin
What is the advantage f Telavancin over Vancomycin?
Once daily dosing due to a 9hour half life
What is the half life of Telavancin?
9 hours
How is Telavancin administered?
IV
When was Telavancin approved by the FDA?
2009
What is the mechanism of action for Vancomycin?
Inhibits cell wall synthesis
What is the mechanism of action for Telavancin?
Inhibits cell wall synthesis
What Glycopeptide disrupts membranes by depolarization?
Telavancin
Telavancin inhibits protein synthesis, like vancomycin and what else?
Disrupts cell membrane through depolarization
What is a disadvantage of Televancin?
More nephrotoxic than vancomycin
Production of Telavancin began when?
delayed until 2011
What are the major multi-drug resistance threats?
MRSA
VRE
Carbapenemase producing enteronacteriaceae
MDR Pseudomonas aeruginosa
MDR Acinetobacter baumannii
Extremely Drug resistant tuberculosis
Author
kyleannkelsey
ID
213545
Card Set
MIC 541-Exam 4- Antimicrobials V-4
Description
MIC 541-Exam 4- Antimicrobials V-4
Updated
4/15/2013, 1:06:40 AM
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