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kyleannkelsey
on FreezingBlue Flashcards.
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MRSA became completely resistant by gaining what?
van genes
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There is a strain of Enterococcus in Michigan that is able to do what?
Transfer van genes to MRSA
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What is red man syndrome?
Vancomycin toxicity
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What types of Vancomycin adversities exist?
- Nephrotoxic
- Ototoxic
- Red man syndrome
- Cardiac effects
- rashes
- phlebitis
- neutropenia
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What can cause neutropenia, phlebitis, red man syndrome, cardiac issues, nephrotoxicity, ototoxicity and skin rashes?
Vancomycin
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What is red man syndrome due to?
histamine effect
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What ways can you reduce red man syndrome from vancomycin?
Slow IV infusion
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Slow IV infusion can reduce what Vancomycin adversities?
Red Man syndrome
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Nephrotoxicity of vancomycin can be reduced by doing what?
Continuous infusions
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Continuous infusions of vancomycin can reduce what adverse effect?
Nephrotoxicity
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Telavancin is related to Vancomycin how?
Synthetic derivative
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What is a synthetic derivative of Vancomycin?
Telavancin
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What is the advantage f Telavancin over Vancomycin?
Once daily dosing due to a 9hour half life
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What is the half life of Telavancin?
9 hours
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How is Telavancin administered?
- IV
- When was Telavancin approved by the FDA?
- 2009
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What is the mechanism of action for Vancomycin?
Inhibits cell wall synthesis
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What is the mechanism of action for Telavancin?
Inhibits cell wall synthesis
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What Glycopeptide disrupts membranes by depolarization?
Telavancin
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Telavancin inhibits protein synthesis, like vancomycin and what else?
Disrupts cell membrane through depolarization
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What is a disadvantage of Televancin?
More nephrotoxic than vancomycin
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Production of Telavancin began when?
delayed until 2011
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What are the major multi-drug resistance threats?
- MRSA
- VRE
- Carbapenemase producing enteronacteriaceae
- MDR Pseudomonas aeruginosa
- MDR Acinetobacter baumannii
- Extremely Drug resistant tuberculosis
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