MIC 541-Exam 4- Antimicrobials VI-4

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  1. What does Tigecycline do mechanistically?
    Binds to the A site of the ribosome
  2. What binding differences does Tigecycline have from Tetracycline?
    • 5 times stronger affinity
    • binds where tetracyclines wont, i.e. methylated
  3. What impact do efflux pumps have on Tigecycline?
    Not really impacted
  4. Efflux pumps are focused on what two bacterial groups?
    Tetracyclines and Macrolides
  5. What is the impact of Ribosmal methylation on tigecycline?
    None, still binds
  6. Tetracycline resistant isolates can be combated with what other drug?
    Tigecycline
  7. Tigecycline is used in monotherapy (T/F)?
    Used to be, now more common in combination
  8. What antibiotic is associated with increased mortality?
    Tigecycline
  9. What is a Ketolide?
    A Macrolide with a ketone
  10. in what way are Ketolides beneficial over macrolides?
    • Active against Macrolide resistant strains
    • evades efflux
    • tighter ribosomal binding than macrolides
  11. What is the trade name of the Ketolide?
    Ketek
  12. What is the generic name for Ketek?
    Telithromycin
  13. How is Telithromycin administered?
    PO
  14. What is Ketek approved for?
    community acquired pneumoniae
  15. Ketek is important socially because?
    The MD creator of Ketek falsified Data to get her drug to the market
  16. What are the negative effects of Ketek?
    liver damage and failure
  17. What did Ketek used to be approved for?
    bronchitis and sinusitis
  18. Can you use Ketolides for sinusitis and bronchitis?
    Ketolides

    • What binding sites in the ribosome do Ketolides bind to?
    • one
  19. What binding sites do Ketolides bind to in the Ribosome?
  20. both
  21. What is the available Streptogramin?
    Synercid = Quinupristin-dalfopristin
  22. What do you use Synercid for?
    • VRE faecium
    • MRSA
  23. What is the mechanism of action for Synercid?
    synergistic ribosomal binding
  24. What killed the Strepogramins?
    Oxazolidanones
  25. What are the Oxazolidinones?
    • Linezoil
    • tedizolid
  26. Linezolid and Tedizolid are in what group antibiotics?
    Oxazolidinones
  27. What is the trade name for Linezolid?
    Zyvox
  28. What is teh generic name for Zyvox?
    Linezolid
  29. What ways can Linezolid be administered?
    PO IV
  30. What is the spectrum for Linezolid?
    All clinically relevant gram positives (including VRE and MRSA)
  31. What type of infection (in what areas of the body) is linezoild most useful?
    • Soft tissue and skin
    • pneumonia
  32. What antibiotic is preferred to Synercid?
    Linezolid
  33. Why is Linezolid preferred over Streptogramins (Synercid)?
    • Wider spectrum
    • Oral availability
    • Fewer side effects
  34. Tedizolid is available for use currently (T/F)?
    False, it is investigational
  35. What is the downside of Linezolid?
    very expensive

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kyleannkelsey
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213573
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MIC 541-Exam 4- Antimicrobials VI-4
Updated:
2013-04-15 03:23:21
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MIC 541 Exam Antimicrobials VI
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MIC 541-Exam 4- Antimicrobials VI-4
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