MIC 541-Exam 4- Antimicrobials VI-5

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Daptomycin is used for what bacteria?

MRSA
Daptomycin is active against what?

the cytoplasmic membrane
What type of antibiotic is Daptomycin?

Lipopeptide
A Lipopetide has what type antibiotic activity?

Membrane active
What antibiotic is membrane active?
- Daptomycin
- Polymixins
What is the spectrum for Daptomycin?

Same as Vancomycin
what is Daptomycin inactive in?

Pneumonia
What is the activity of Polymixins?

Cell membrane active
What is the problem of Polymixins?

Very toxic
What are the toxic issues of Polymixins?
- irreversible or nearly irreverable neurotoxic effects
- nephrotoxicity
What pathogens may necessitate polymixin use?
- P. aeruginosa
- Acinetobacter
- multiple resistant Enterobacteriaceae
Resisatnce is emerging (T/F)?
- True
- Enterobacteriaceae especially
What common use item has polymixins in it?

Neosporin
Neosporin is safe in the blood stream (T/F)?

False, it is very dangerous because of the polymixins
Patients with tuberculosis need to have what combination treatment?

Two (never one) Anti-mycobacterial drugs at once to prevent resistance from developing
What drugs should never be used alone:
- Rifampin
- Isonazid
- Ethambutol
- Paraminosalycylic acid
What drugs indicate a mycobacterial infection that necessitates the use of two Antimycobacterial agents?

Rifampin, Isonazid, Ethambutol and Paraaminosalysylic acid