MIC 541-Exam 4- Antimicrobials VII-2
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Where are resistance to flouroquinolone coded?
What type of coding for resistance against Flouroquinolones developed recently?
What are qnr genes?
plasmid mediated quinolone resistance genes
How do qnr genes protect bacteria?
protect Type II topoisomerases from flouroquinolones
How do bacteria protect themselves against quiolones other than qnr?
- decreased porins into the cytoplasm
What altered targets have developed against flouroquinolones?
What is QRDR?
Quinolone resistance determining region
Whay is QRDR important :
most resistance genes here
Streptococcus pnemoniae has lots of little resistance to flouroquinolones?
Why is Streptococcus resistance so minimal to flouroquinolones?
- Not used in children
- Children is where resistance develops
- Could cause joint problems
What group are flouroquinolones not used for?
Streptococcus pneumoniae is not very resistant to what?
How do you prevent resistnace?
- More potent drugs
- Drugs with pharmacokinetcis (higher concentrations in the body)
P. aeruginosa has what unique feature for pathogens?
Why will Pseudomonas develop resistance quickly to flouroquinolones?
It develops resistance quickly to everything because of its large geneome
What type of therapy should be used for Pseudomonas?
Combination (due to resistance factors)
Why should you give combination therapies to rid of pseudomonas infections?
it develops resistance so easily
Carbapenem and flouroquinolone is a good combination therapy for what?
Why is Cabapenem and flouroquinolone an important combination in the lab?
It prevents the development of resistance
Are Flouroquinolones safe?
- They have rare adverse effects
What are the rare effects of flouroquinolones?
- may feel stimulated like caffeine
- CNS toxicity
What is the rate of adverse drug reactions for flouroquinolones?
What drugs have fewer adverse reactions?
Cephalosporins and macrolides
What antibiotics have more adverse reactions?
Flouroquinolones may cause what colonization?
MRSA and C. diff
What would you like to do?
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