Slate Training - PI

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Author:
bwallis
ID:
213684
Filename:
Slate Training - PI
Updated:
2013-04-19 11:01:18
Tags:
Testopel
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Description:
Testopel - PI
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  1. What are Androgens?
    Steroids that develop and maintain primary and secondary male sex characteristics.
  2. Inactive Ingredients in Testopel. (2)
    • Stearic Acid USP 0.2mg
    • polvinylpyrolidone USP 2mg
  3. What type of testosterone in Testopel pellets?
    Crystalline Pellets
  4. Endogenous Androgens
    Responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics.
  5. What do Androgens do to protein anabolism and protein catabolism?
    Androgens increase protein anabolism and decrease protein catabolism.
  6. How do androgens affect children and adolescence? (4)
    • Androgens are responsible for the growth spurt of adolescence.
    • Termination of linear growth in adolescence.
    • In children, androgens accelerate linear growth
    • may cause disproportionate advancement in bone maturation
  7. How do Androgens stimulate the production of red blood cells?
    Enhancing the production of erythropoietic stimulating factor.
  8. What happens during exogenous administration of androgens?
    Endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinzing hormone (LH).
  9. What happens at large doses of exogenous androgens?
    spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).
  10. How is Testosterone bound in plasma?
    98% bound to a specific testosterone-estradiol binding globulin and about 2% is free.
  11. How is testosterone excreted?
    • 90% is excreted as glucuronic and sulfuric acid conjugates of testosterone and its metabolites
    • 6% of a dose is excreted in feces
  12. When are androgens indicated for replacement therapy?
    In conditions associated with a deficiency or absence of endogenous testosterone.
  13. Sertoli Cells? (2)
    • Aid in the maturation of sperm cells; part of spermatogenesis.
    • Also called nurse cells.
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  14. What is the recommended conversion of IM testosterone to Testopel?
    For every 25mg of IM Testosterone 2 Testopel 75mg should be implanted.
  15. What are the stated indications of Testopel and Primary Hypogonadism on the PI? (5)
    • Cryptorchidism -absence of 1 or both testes
    • Bilateral Torsion
    • Orchitis - swelling/inflammation of testicles
    • Vanishing Testes Syndrome
    • Orchidectomy - surgical removal of 1 or both testes
  16. What are the contraindications of Androgens on PI?
    • Men with Breast Cancer or Prostate cancer
    • Pregnant Women
  17. What are the 3 risk warnings that men have when treated with Androgens according to PI?
    • Prostatic Hypertrophy - Same as BPH
    • Prostatic Carcinoma
    • Gynecomastia (most common) - benign enlargement of breast tissue in males
  18. What are the 2 most common causes of pellets to slough out?
    • Implanted too superficially
    • neglect in regard to aseptic precautions
  19. What are the side effects of androgens on PI? (5)
    • Too frequent erections
    • Nausea
    • Vomiting
    • Changes in skin color
    • ankle swelling
  20. Pregnancy Category
    X
  21. Are Androgens excreted through human milk?
    Unknown
  22. Another adverse reaction to Testopel on PI is Oligospermia.  What is that?
    Semen with a low concentration of sperm
  23. How many acute overdoses of androgens have been reported?
    Zero
  24. What are Testopel (Testosterone Pellets) classified as?
    Schedule III controlled substance under the Anabolic Steroid Act of 1990
  25. How is Testopel absorbed?
    • 1/3 of the material in first month
    • 1/4 in second month
    • 1/6 in third month
  26. How is Testopel supplied



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    One pellet per vial in boxes of 10 and 100



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    • // ]]>

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