Phar442 MOA of PD/MS/AD/Anti-psychotic drugs and drugs of abuse

Card Set Information

Author:
timothy.pdlt
ID:
213967
Filename:
Phar442 MOA of PD/MS/AD/Anti-psychotic drugs and drugs of abuse
Updated:
2013-04-16 20:31:42
Tags:
PD MS AD FGA SGA abuse
Folders:

Description:
MOA
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user timothy.pdlt on FreezingBlue Flashcards. What would you like to do?


  1. benztropine
    • anticholinergic
    • smooths ACh/DA activity in the basal ganglia
    • inhibit DA transporter?
    • NMDA antagonist?
  2. trihexyphenidyl
    • anticholinergic
    • smooths ACh/DA activity in the basal ganglia
    • inhibit DA transporter?
    • NMDA antagonist?
  3. dopamine
    DA1R and DA2R agonist at nigrostriatal
  4. LDopa
    DA analogue at DA1/2R
  5. carbidopa
    peripheral ALAA decarboxylase I
  6. benserazide
    peripheral ALAA decarboxylase I
  7. amantadine
    • increase DA
    • inhibit DA reuptake
    • NMDA antagonist
  8. bromocriptine
    • D2 agonist (++)
    • 5HT and alpha agonist
    • ergot
  9. lisuride
    • D2 (+++)>D1 (+) agonist
    • 5HT and alpha agonist
    • ergot
  10. pergolide
    • D2 (+) agonist
    • 5HT, alpha, and beta agonist
    • ergot
  11. cabergoline
    • D2 (+++)> D1 (+/0) agonist
    • 5HT and alpha agonist
    • ergot
  12. apomorphine
    D2 (+++)> D1 (+) agoinst
  13. pramipexole
    D2 agonist (+++)
  14. ropinirole
    D2 (+++) agonist
  15. entacapone
    peripheral COMT I
  16. talcapone
    PNS/CNS COMT I
  17. selegiline
    • selective, irrevesible MAO-B I
    • inhibit tyramine reuptake
    • inhibit NE release
    • reduce oxidative damage (DA radicals)
    • inhibit MPTP-->MPP+

    (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-->(1-methyl-4-phenylpyridinium)
  18. rasagiline
    highly selective irreversible MAO-B I
  19. safinamide
    MAO-B I
  20. rotigotine
    DA agonist
  21. IFN-B1a
    • (glycosylated)
    • inhibition of peripheral Th1 cytokine
    • BBB: decrease T cell MMPs and endothelial VCAM-1= decrease CNS infiltration

    • (Matrix metalloproteinase)
    • (vascular cell adhesion molecule 1)
  22. IFN-B1b
    • inhibition of peripheral Th1 cytokine
    • BBB: decrease T cell MMPs and endothelial VCAM-1= decrease CNS infiltration

    • (Matrix metalloproteinase)
    • (vascular cell adhesion molecule 1)
  23. glutiramer acetate
    • PNS: promotes Th1-->Th2 shift
    • BBB: no effect on MMPs/VCAM-1
    • CNS: bystander suppresion by Th2
  24. natalizumab
    inhibit alpha-2 integrin= decrease lymphocyte/monocyte adhesion= decrease infiltration
  25. opioids
    • mu agonist
    • kappa/sigma activation= decrease GABA= increase DA (disinhibition of DA N)
  26. clonidine
    • alpha-2 agonist
    • reduces firing of NE N (inhibited by opioids)
  27. meperidine
    • mu agonist
    • 5HT reuptake inhibitor
  28. tramadol
    • weak mu agonist
    • blocks 5HT/NE reuptake
  29. cocaine
    • block DA reuptake
    • anesthetic at high doses
  30. amphetamines
    • cause DA release by reverse vesicular transporter
    • block DA/NE reuptake
    • block MAO
  31. methcathinone
    analogue of methamphetamine and and cathinone
  32. delta-9-tetrahydrocannabinol
    • presynaptic CB1 agonist= inhibit Na+/Ca+ influx and K+ efflux
    • disinhibition of DA neurons
  33. lysergic and diethylamide
    5HT R partial agonist
  34. mescaline
    5HT R partial agonist
  35. psilocybin
    5HT R partial agonist
  36. nicotine
    • decrease DA release in the nucleus accumbens
    • decrease Glu= increase DA= euphoria
    • GABA spikes before falling
    • DA N excitation and disinhibition?
  37. alcohol
    • increase nicotinic/5HT3/GABA activity
    • increase DA release
    • block NMDA/kainate
    • inhibit Ca+2 channels
    • stimulates Gs
    • change in lipid composition
    • DA N excitation and disinhibition?
  38. BDZ
    • bind GABAa-gamma subunit= increase Cl- conductance= removal of inhibitory tone= increase Glu-mediated
    • DA N disinhibition
  39. amytal
    short-acting BARB
  40. pentathiol
    short-acting BARB
  41. nembutal
    intermediate-acting BARB
  42. seconal
    intermediate-acting BARB
  43. tuinal
    intermediate-acting BARB
  44. phenobarbital
    long-acting BARB
  45. gamma-hydroxy butyrate (GHB)
    • activation of pre-/post-synaptic GABAb R
    • GHB R binding
  46. donepezil
    selective non-competitive AChEI
  47. rivastigmine
    non-competitive AChEI and butyrylAChE I
  48. tacrine
    AChEI
  49. galantamine
    • enhance nicotine-mediated nicotinic activity by binding all alpha subunits
    • weak competitive AChEI and butyrylAChE I
  50. memantine
    • non-competitive NMDA antagonist
    • non-competitive nicotinic R antagonist at alpha7/8/9 subunits
    • facilitates Glu synaptic release from hippocampal and cortical neurons
    • non-competitive 5HT3 R blockate
  51. ketamine
    NMDA antagonist
  52. DM
    NMDA antagonist
  53. ondasetron
    5HT blocker
  54. tropisetron
    5HT blocker
  55. clioquinol
    beta-amyloid aggregation inhibitor
  56. alzhemed
    beta-amyloid aggregation inhibitor
  57. cevimeline
    M1/3 selective agonist
  58. phenserine
    potent AChEI
  59. gingko biloba
    • increase cerebral blood flow
    • beta-amyloid aggregation inhibitor in-vivo at high concentration
    • flavonoids (6%)= antioxidants
  60. FGA
    • D2 antagonist
    • H1/alpha-1/M1 antagonist
  61. chlorpromazine
    low-potency FGA
  62. fluphenazine
    FGA
  63. haloperidol
    high-potency FGA
  64. pimozide
    high-potency FGA
  65. perphenazine
    high-potency FGA
  66. loxapine
    FGA
  67. thiothixine
    FGA
  68. trifluoperazine
    FGA
  69. SGA
    • D2 antagonist
    • H1/alpha-1/M1 antagonist
    • 5HT2A antagonist
  70. aripiprazole
    D2*>D3>5HT1A*>5HT2A>5HT2C>D4>alpha-1>H1>D1>M1
  71. asenapine
    5HT2C>5HT2A>D3>H1>D4>alpha-1>D2>D1>M1
  72. clozapine
    H1>M1>alpha-1>5HT2A>5HT2C>D4>D1>D2>D3>5HT1A*
  73. lurasidone
    5HT2A>D2>5HT1A>alpha-1>D1>5HT2C>H1>M1
  74. olanzapine
    H1>5HT2A>M1>5HT2C>D2>D4>D1>D3>alpha-1>5HT1A
  75. paliperidone
    5HT2A>D2>H1>D3>alpha-1>D1>5HT2C>D4>5HT1A>M1
  76. quetiapine
    H1>alpha-1>5HT2A>D2>5HT1A*>D1>D3>M1>D4>5HT2C
  77. risperidone
    5HT2A>alpha-1>D2>D4>D3>5HT2C>H1>5HT1A>D1>M1
  78. ziprasidone
    5HT2A>5HT2C>5HT1A*>D2>D3>alpha-1>D4>H1>D1>M1

What would you like to do?

Home > Flashcards > Print Preview