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Name the general MOA of anti seizure drugs
- 1. decrease neuron excitability
- 2. increase seizure threshold
- 3. block abnormal nerve stimulus
What are the general AE of anti-seizure drugs
drowsy, nausea, vomiting, lethargy, Stevens-Johnsons-Syndrome, lupus erythemat, headache, dysrhythmias, bone marrow suppression (anemia, usually WBC)
T/F: are you allowed to take antiseizure drugs with meals?
TRUE: as long as it is not crushed and taken at the same time everyday
Which antiseizure drugs cause HTN and dysrhythmias if given IV too fast?
- phenytoin and fosphenytoin
- *phenytoin is in both drug names
As a LPN what are you monitoring in pts taking antiseizure drugs?
signs of infection, hypotension, pulse, respiration, IV site
What are some pt edu points for antiseizure drugs?
drugs will make you drowsy - avoid driving and operating heavy machinery, teratogenic, no alcohol, medic bracelet, med adherance
Name the anticonvulsant drugs that depress the CNS
- Diazepam (Valium) - bradycardia, cardiovascular collaspe, possible dependence
- Phenobarbital (Solfoton) - decrease respiration, bradycardia, apena, angio edema, SJS
name the anticonvulsant drugs that stops seizures by alterin the exchange of Na ions
- Phenytonin (Dilantin) - IV, WBC anemias, Hepatitis, hypotension, SJS
- Carbamazepine (Tegretol) - increases seizures, heart failure, anemia, SJS
- Topiramate (Topamax) - leukopenia, tremor, taxia, metabolic acidosis
- Ethosuximide (Zarontin) - leukopenia, lupus, SJS,
Name the anticonculsant drugs that stop seizures by increasing GABA
- Valporate (Depakene) - pancreatitis, hemorrhage, hepatoxicity, SJS
- Tiagabine (Gabitril) - ataxia, leukopenia
- Felbamate (Felbatol) - hepatic failure, ataxia, tremors, visual disturbances