PHA 327 - Exam 2 - Preformulation 2

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kyleannkelsey
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214483
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PHA 327 - Exam 2 - Preformulation 2
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2013-04-19 09:52:07
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PHA 327 Exam Preformulation
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PHA 327 - Exam 2 - Preformulation 2
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  1. The particle size can effect what properties?
    • Dissolution rate
    • Absorption rate
    • Content conformity
    • Taste, texture, color and stability
  2. Dissolution rate can be affected by what physical property?
    Particle size
  3. The Absorption rate can be affected by what physical property?
    Particle size
  4. The Content conformity can be affected by what physical property?
    Particle size
  5. The Color, texture, and stability can be affected by what physical property?
    Particle size
  6. What physical property can effect dissolution rate, absorption rate, content conformity, color, texture and stability?
    Particle size
  7. Sieving is used to determine what physical property?
    Particle size of those over 44 microns
  8. What is the limitation of sieving?
    Can only be used for large particle sizes (over 44 microns)
  9. What four methods are used for determining particle size?
    • Sieving
    • Microscopy
    • Sedimentation
    • Stream Scanning
  10. What physical property can be determined using stream scanning, sedimentation, microscopy and Sieving?
    Particle size
  11. What is the downside of using microscopy to determine particle size?
    Slow and tedious
  12. What range of particle sizes can be detected using Sedimentation?
    3-250 microns
  13. What general method type is Stream scanning?
    Electronic particle sizing
  14. What is the downside of stream scanning for particle size?
    No information on the shape
  15. What does the partition coefficient represent?
    The ratio of a compound in a mixture of two immiscible phases
  16. What is the crystal habit?
    The overall morphology of the crystal (e.g. columnar, needle, tabular, plate)
  17. What does the Octonal-water partition coefficient measure?
    The lipophilicity of the drug
  18. What type of partition coefficient could be useful in determining the lipophilicity of a drug?
    The Octonal water partition coefficient
  19. How would you measure the lipophilicity of a drug?
    The Octonal-water partition coefficient
  20. What is the equation for the partition coefficient?
    • P= conc. of drug in octonal/Con. of drug in water
    • for an ionizable drug:
    • P = conc. of the drug in octonal/ 1-degree of ionization x conc. of drug in water
  21. Many drugs are acidic and basic in nature (T/F)?
    True
  22. The pKa of a drug can depend on what?
    The pH of the medium/formulation containing the drug
  23. What can be affected by the pKa of a drug?
    • Absorption
    • Distribution
    • Elimination
    • Extent of ionization
    • Extent of dissociation
  24. The extent of dissociation and ionization is controlled by what physical characteristic?
    pKa
  25. The pKa controls the absorption, elimination and distribution of a drug by controlling what factors?
    The extent of ionization and dissociation
  26. Why is solubility important to the dosage form?
    Water Insoluble compounds may exhibit either incomplete or erratic absorption
  27. In what ways can solubility issues be resolved with preformulation work?
    • Preparation of:
    • Soluble salts or esters
    • Solubilization by complexation
    • Microionization
    • Solid dispersion
  28. Solubility is a colligative property (T/F)?
    True
  29. Define Solubility:
    the quantity of a particular substance that can dissolve in a particular solvent at a particular temperature
  30. What conditions control solubility?
    • Temperature
    • Time
  31. Solubility is usually given with what units?
    mg/mL
  32. What two type of solubility are there?
    • Kinetic
    • Equilibrium
  33. Is equillibrium solubility an intrinsic component of a compound or can it be altered?
    • It is intrinsic
    • It can only be altered by "tricks" of dosage forms
  34. Equillibrium solubility requires more time, because:
    You have to reach equillibrium
  35. Kinetic solubility is defined as:
    The solubility at a certain time interval
  36. Define Very soluble:
    Can dissolve up at a conc. of 1:1 solvent:solute
  37. Define Freely Soluble:
    Can dissolve at a conc. of 10:1 solvent:solute
  38. Define Soluble (per USP):
    Can dissolve at a conc. of 10-30:1 solvent:solute
  39. Define Sparingly Soluble:
    Can dissolve at a conc. of 30-100:1 solvent:solute
  40. Define Slightly soluble:
    Can dissolve up a conc. of 100-1000:1 solvent:solute
  41. Define Very slightly soluble:
    Can dissolve up a conc. of 1000-10,000:1 solvent:solute
  42. Define Practically insoluble:
    Can dissolve up a conc. of 10,000+:1 solvent:solute
  43. What is the term for a solute that can dissolve at a ratio of 1:<1 solvent:solute?
    Very soluble
  44. What is the term for a solute that can dissolve at a ratio of 10:1 solvent:solute?
    Freely soluble
  45. What is the term for a solute that can dissolve at a ratio of 10-30:1 solvent:solute?
    Soluble
  46. What is the term for a solute that can dissolve at a ratio of 30-100:1 solvent:solute?
    Sparingly soluble
  47. What is the term for a solute that can dissolve at a ratio of 100-1000:1 solvent:solute?
    Slightly soluble
  48. What is the term for a solute that can dissolve at a ratio of 1000-10,000:1 solvent:solute?
    Very Slightly Soluble
  49. What is the term for a solute that can dissolve at a ratio of -qHelloe0,000+:1 solvent:solute?
    Practically insoluble
  50. The dissolution rate may be affected by what?
    • chemical form
    • crystal form
    • particle size
    • surface properties

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