PHA 327 - Exam 2 - Tablets 1

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  1. What is a tablet?
    A solid dosage form containing medicinal agents + or - a diluents
  2. What are the two manufacturing classifications for tablets?
    • Molded tablets
    • Compressed tablets
  3. What are molded tablets?
    tablets that are made by dampening the powder prior to molding
  4. What is a compressed tablet?
    Solid dosage forms with exipients prepared by compaction
  5. What are the advantages of Tablets?
    • Convenient and easy to use-patients like
    • less expensive
    • physically and chemically stable
    • can have special release profiles
    • Most tamper proof of PO dosage forms
    • Easy to produce and store
  6. What disadvantages were discussed for tablets?
    • Psychological fear of swallowing for some patients
    • Impractical to prepare extemporaneously
  7. What routes of administration exists for tablets?
    • Oral
    • Buccal
    • Sublingual
    • Chewable
    • Effervescent
    • Lozenges
  8. What is a buccal tablet designed to do?
    Dissolve slowly between cheek and teeth
  9. What is a Sublingual tablet designed to do?
    Dissolve rapidly under the tongue
  10. What are oral tablets designed to do?
    Be taken by mouth with water
  11. What are lozenges designed to do?
    Be sucked and held in the mouth for local effects
  12. What types of coating types exist for tablets?
    • Sugar
    • Enteric
    • Film
  13. What is a standard compressed tablet?
    tablet prepared by direct compression, dry granulation or wet granulation
  14. What are multiple compressed tablets?
    Tablets designed to enable separation of incompatible components
  15. Why do we coat tablets with sugar?
    • Protect from moisture
    • Mask odor
    • Flavor
  16. Why would you make an enteric coated tablet?
    • To protect the drug from gastric acid degradation
    • To protect the gastric mucosa from the drug
  17. What is a film coated tablet?
    A tablet covered in a soluble or insoluble polymer film
  18. What is a sustained release tablet designed to do?
    Release an initial therapeutically effective amount of drug and then maintain that level over a long duration
  19. What is an exipient?
    inert substance used to give a preparation a certain form or consistency
  20. What is the term for an inert substance used to give a preparation a certain consistency or form?
  21. What are different types of exipients?
    • Fillers
    • Diluents
    • Bulking agents
    • Binders
    • Disintegrants
  22. Fillers diluents and bulking agents are used to do what in tablet manufacturing?
    Make a reasonably sized tablet
  23. What are binders used for in manufacturing of tablets?
    • To bind powders in wet granulation
    • To bind granules together during compression
  24. What are disintegrates used for in tablet manufacturing?
    promote rapid release of the drug
  25. What is another term for diluents?
  26. Name the three insoluble fillers mentioned in class:
    • Calcium sulfate, dihydrate
    • Calcium phosphate, dibasic or tribasic
    • Starch: microcrystalline cellulose
  27. What are Calcium sulfate, calcium phosphate and monocrystalline cellulose all used for in tablet s?
    Insoluble fillers
  28. What four soluble fillers were discussed in class?
    • lactose
    • sucrose
    • dextrose
    • mannitol
  29. Lactose, sucrose, dextrose and mannitol are all used for what in tablet formulation?
    Soluble fillers
  30. What were the seven binders discussed in class?
    • Corn starch USP
    • Starch 1500
    • Gelatin
    • Acacia
    • PVP
    • Methyl cellulose
    • Sodium Carboxymethyl cellulose
  31. Corn starch USP, Starch 1500, Gelatin, Acacia, PVP, Methyl Cellulose and Sodium Carboxymethyl cellulose are used for what is tablet formulation?
  32. What binders are used at a concentration of 5-10%?
    • Corn Starch USP
    • Starch 1500
  33. What binders are used at a concentration of 5-20%?
    • Acacia
    • PVP
  34. What binders are used at a concentration of 2-10%?
    • Gelatin
    • Methyl Cellulose
    • Sodium Carboxymethyl cellulose
  35. Corn starch USP and Starch 1500 are used at what concentration as binders for tablets?
  36. Acacia and PVP are used at what concentration as binders for tablets?
  37. Gelatin, Methyl cellulose and sodium carboxymethyl cellulose are used at what concentration as binders in tablet formation?
  38. What are the three methods used for incorporation of disentigrants into a tablet?
    • Internal addition
    • External addition
    • Combination internal and external
  39. How is internal incorporation of disintigrants performed?
    Disintigrants are mixed into the powders before granulation
  40. How is external incorporation of disintigrants performed?
    Disintigrants are mixed into the granules prior to compression
  41. What is the most efficient method of incorporating disintigrants into tablets?
    Use both internal and external addition
  42. Describe the action of disintigrants in the stomach:
    They swell when they contact gastric juices and exert mechanical pressure from within the tablet to force it to break apart
  43. Name the disintigrants discussed in class:
    • Starch USP
    • Starch 1500
    • Microcrystalline cellulose
    • Alginic acid
    • Guar gum
    • Methylcellulose Sodium carboxymethyl cellulose
Card Set:
PHA 327 - Exam 2 - Tablets 1
2013-04-19 20:30:01
PHA 327 Exam Tablets

PHA 327 - Exam 2 - Tablets 1
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