PHA 327 - Exam 2 - Tablets 2

Card Set Information

Author:
kyleannkelsey
ID:
214535
Filename:
PHA 327 - Exam 2 - Tablets 2
Updated:
2013-04-19 17:44:46
Tags:
PHA 327 Exam Tablets
Folders:

Description:
PHA 327 - Exam 2 - Tablets 2
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user kyleannkelsey on FreezingBlue Flashcards. What would you like to do?


  1. What concentration of Starch USP should be used to creating a disintegrating action?
    5-20%
  2. What disintegrating agents should be added at a concentration of 5-15%?
    • Starch 1500
    • Microcrystalline Cellulose
    • Alginic Acid
  3. What disintegrating agent should be used at a concentration of 5-20%?
    Starch USP
  4. What disintegrating agent should be used at a concentration of 5-10%?
    Methylcellulose, Sodium Carboxymethylcellulose
  5. What concentration should Sodium carboxymethyl cellulose and Methylcellulose be used at?
    5-10%
  6. What disintegrating agent should be used at a concentration of 2-8%?
    Guar Gum
  7. What concentration should Guar Gum be used at?
    2-8%
  8. What are glidants?
    Substances used to reduce friction between the particles in a dosage form to improve the flow properties
  9. What is the term for substances used to reduce friction between the particles in a dosage form to improve the flow properties?
    Glidants
  10. What are anti-adherents?
    Substances that are meant to reduce adhesion of the granules to the punch faces and dies
  11. What is the term for substances that are meant to reduce adhesion of the granules to the punch faces and dies?
    Anti-adherents
  12. What are lubricants used for in tablet manufacturing?
    Reduce friction between the tablet and the walls of the die cavity
  13. What can you use to reduce friction between the tablet and the walls of the die cavity?
    Lubricants
  14. How can flavorings be incorporated into tablets?
    • By spraying dry granules with alcoholic solutions
    • OR
    • Incorporated into the lubricant
  15. What forms are flavoring agents available in?
    • oils
    • spray dried beadlets
  16. What machine is used to compress tablets?
    Tablet press
  17. What are the five components of a tablet press?
    • Hopper
    • Feed frame
    • Dies
    • Punches
    • Cams
  18. What does the hopper of a tablet press do?
    Stores materials that will be compressed
  19. What part of the tablet press stores materials that will be compressed?
    Hopper
  20. What part of the tablet press distributes materials into the dies?
    Feed frame
  21. What does the feed frame of a tablet press do?
    Distributes materials into the dies
  22. What part of the tablet press control the size and shape of the tablet ?
    Dies
  23. What does the Dies of a tablet press do?
    Control the size and shape of the tablet
  24. What does the punches of a tablet press do?
    Compact the materials within the dies
  25. What part of the tablet press compacts the materials within the dies?
    Punches
  26. What does the Cams of a tablet press do?
    Guide the punches
  27. What part of the tablet press guides the punches?
    Cams
  28. Describe the three very basic steps in tablet pressing as described in class:
    • 1.) Powders fed into the dies
    • 2.) Powders compressed between punches
    • 3.) Tablets ejected from the dies
  29. Describe a rotary tablet press:
    Compression rolls move over upper and lower punches compressing tablets in the dies
  30. What three methods are available for making the tablet granulation for compressed tablets?
    • Direct compression
    • Dry granulation
    • Wet granulation
  31. What is the purpose of the wet and dry granulation processes?
    To improve the flow of and compressibility of powders that would otherwise be unsuitable for compression
  32. What ways can you improve the flow and compressibility of powders that would otherwise be unsuitable for tablet compression?
    Wet and dry granulation
  33. Describe direct granulation:
    process of compression of mixed powders into a tablet without intermediate granulation steps
  34. Name the five direct compression diluents discussed in class:
    • Lactose (spray dies lactose)
    • Microcrystalline cellulose
    • calcium sulfate
    • dibasic calcium phosphate
    • starch 1500
  35. What are the advantages of direct compression?
    • Less expensive
    • No heat or moisture used
    • Increased surface area for rapid dissolution
    • More stable tablets

What would you like to do?

Home > Flashcards > Print Preview