PHA 327 - Exam 2 - Tablets 2
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What concentration of Starch USP should be used to creating a disintegrating action?
What disintegrating agents should be added at a concentration of 5-15%?
- Starch 1500
- Microcrystalline Cellulose
- Alginic Acid
What disintegrating agent should be used at a concentration of 5-20%?
What disintegrating agent should be used at a concentration of 5-10%?
Methylcellulose, Sodium Carboxymethylcellulose
What concentration should Sodium carboxymethyl cellulose and Methylcellulose be used at?
What disintegrating agent should be used at a concentration of 2-8%?
What concentration should Guar Gum be used at?
What are glidants?
Substances used to reduce friction between the particles in a dosage form to improve the flow properties
What is the term for substances used to reduce friction between the particles in a dosage form to improve the flow properties?
What are anti-adherents?
Substances that are meant to reduce adhesion of the granules to the punch faces and dies
What is the term for substances that are meant to reduce adhesion of the granules to the punch faces and dies?
What are lubricants used for in tablet manufacturing?
Reduce friction between the tablet and the walls of the die cavity
What can you use to reduce friction between the tablet and the walls of the die cavity?
How can flavorings be incorporated into tablets?
- By spraying dry granules with alcoholic solutions
- Incorporated into the lubricant
What forms are flavoring agents available in?
What machine is used to compress tablets?
What are the five components of a tablet press?
- Feed frame
What does the hopper of a tablet press do?
Stores materials that will be compressed
What part of the tablet press stores materials that will be compressed?
What part of the tablet press distributes materials into the dies?
What does the feed frame of a tablet press do?
Distributes materials into the dies
What part of the tablet press control the size and shape of the tablet ?
What does the Dies of a tablet press do?
Control the size and shape of the tablet
What does the punches of a tablet press do?
Compact the materials within the dies
What part of the tablet press compacts the materials within the dies?
What does the Cams of a tablet press do?
Guide the punches
What part of the tablet press guides the punches?
Describe the three very basic steps in tablet pressing as described in class:
- 1.) Powders fed into the dies
- 2.) Powders compressed between punches
- 3.) Tablets ejected from the dies
Describe a rotary tablet press:
Compression rolls move over upper and lower punches compressing tablets in the dies
What three methods are available for making the tablet granulation for compressed tablets?
- Direct compression
- Dry granulation
- Wet granulation
What is the purpose of the wet and dry granulation processes?
To improve the flow of and compressibility of powders that would otherwise be unsuitable for compression
What ways can you improve the flow and compressibility of powders that would otherwise be unsuitable for tablet compression?
Wet and dry granulation
Describe direct granulation:
process of compression of mixed powders into a tablet without intermediate granulation steps
Name the five direct compression diluents discussed in class:
- Lactose (spray dies lactose)
- Microcrystalline cellulose
- calcium sulfate
- dibasic calcium phosphate
- starch 1500
What are the advantages of direct compression?
- Less expensive
- No heat or moisture used
- Increased surface area for rapid dissolution
- More stable tablets
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