PHA 327 - Exam 2 - Capsules 2
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What different types of content can be placed in soft gel capsules?
- Solutions of solids in liquid
- Suspensions of solids in liquids
What type of liquids is most commonly used in humans?
What characteristics should liquid intended for soft gel encapsulation and suspensions have?
- Air free
- Flow under gravity at room temperature
- pH between 2.5 and 7.5
What characteristics should a liquid intended for soft gel encapsulation not have?
- High proportion of plasticizers (propylene glycol, glycerol)
- Water miscible and volatile liquids as major constituents (ethyl alcohol)
Why should high proportions of plasticizers not be encapsulated in soft gel caps?
They have a softening effect in the shell
What capsule content can have a softening effect on the shell of a soft gel cap?
Plasticizers like propylene glycol and glycerol
Name three examples (as presented in class) that should not be encapsulated in soft gel caps:
- Ethyl alcohol
- Propylene Glycol
What should empty capsules be inspected for prior to use?
- Physical dimensions
- Wall thickness
- Overall join length
- Air bubbles
- Dents, cracks, loose caps
What should filled capsules be inspected for prior to use?
- Content uniformity
- Moisture content
- Fill weight
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