PHA 327 - Exam 2 - Capsules 2

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Author:
kyleannkelsey
ID:
214717
Filename:
PHA 327 - Exam 2 - Capsules 2
Updated:
2013-04-20 21:12:08
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PHA 327 Exam Capsules
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PHA 327 - Exam 2 - Capsules 2
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  1. What different types of content can be placed in soft gel capsules?
    • Liquids
    • Solutions of solids in liquid
    • Suspensions of solids in liquids
    • Solids
  2. What type of liquids is most commonly used in humans?
    Oils
  3. What characteristics should liquid intended for soft gel encapsulation and suspensions have?
    • Homogenous
    • Air free
    • Flow under gravity at room temperature
    • pH between 2.5 and 7.5
  4. What characteristics should a liquid intended for soft gel encapsulation not have?
    • High proportion of plasticizers (propylene glycol, glycerol)
    • Water miscible and volatile liquids as major constituents (ethyl alcohol)
  5. Why should high proportions of plasticizers not be encapsulated in soft gel caps?
    They have a softening effect in the shell
  6. What capsule content can have a softening effect on the shell of a soft gel cap?
    Plasticizers like propylene glycol and glycerol
  7. Name three examples (as presented in class) that should not be encapsulated in soft gel caps:
    • Ethyl alcohol
    • Glycerol
    • Propylene Glycol
  8. What should empty capsules be inspected for prior to use?
    • Physical dimensions
    • Wall thickness
    • Length
    • Overall join length
    • Air bubbles
    • Dents, cracks, loose caps
  9. What should filled capsules be inspected for prior to use?
    • Content uniformity
    • Moisture content
    • Fill weight
    • Disintegration
    • Dissolution
    • Stability
    • Leaking

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