PHA 327 - Exam 2 - Ointments 3
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Are there lipids in water soluble bases?
What ointment base is a synthetic base?
water soluble base
What are the advantages of a Synthetic base?
- Relatively inert
- Does not support mold growth
- Little hydrolysis (stable)
What are the disadvantages of a Synthetic base?
- May dehydrate skin
- May hinder percutaneous absorption
What six things do you need to consider when choosing an appropriate base?
- release rate of a drug from the base
- enhancement of percutaneous absorption
- Stability of the drug in the ointment
- Drug influence on the consistency
- Desire of occlusion
- Desire for easy removal
What are the six ideal properties of an ointment base?
- Ways to remove
- Should have good absorption
- Good release properties
What are the two general means of ointment preparation?
- Mechanical incorporation
What is Fusion?
Combining components by melting together and cooling (while stirring) until congealed
What is the term for combining components by melting and cooling while stirring until congealed?
For what type of base would you use Mineral oil as a Levigating agent?
- Oily bases
- Bases with oil as the external phase
For an oily base ointment or one where an oil is the external phase, what type of Levigating agent would you use?
For bases where water is the external phase what Levigating agent would you use?
Glycerin is used as a Levigating agent for what type of bases?
Bases with water as the external phase
How much Levigating agent should be used?
Levigating agent should be in equal volume to the solid material
What type of spatula should be used for the preparation of ointments?
A long one with a broad base
When is fusion used?
- For bases that contain solids of a greater melting point
- Solid medications that are readily soluble in melted bases
What type of ointment preparation is most ideal for a base that contains solids of a higher melting point?
What type of ointment preparation is used for solid medications that are readily soluble in melted bases?
How do you perform Fusion?
- Melt the oil phases separately starting with the highest melting point
- The water phase is heated separately to a temp > the temp of the oil phase
- The two phases are combined by agitation
- Volatile materials are added after cooling
What would you like to do?
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