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PHA 327 - Exam 2 - Ointments 3
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Are there lipids in water soluble bases?
No
What ointment base is a synthetic base?
water soluble base
What are the advantages of a Synthetic base?
Relatively inert
Does not support mold growth
Little hydrolysis (stable)
What are the disadvantages of a Synthetic base?
May dehydrate skin
May hinder percutaneous absorption
What six things do you need to consider when choosing an appropriate base?
release rate of a drug from the base
enhancement of percutaneous absorption
Stability of the drug in the ointment
Drug influence on the consistency
Desire of occlusion
Desire for easy removal
What are the six ideal properties of an ointment base?
Non-irritating/dehydrating/greasy
Compatible
Stable
Ways to remove
Should have good absorption
Good release properties
What are the two general means of ointment preparation?
Mechanical incorporation
Fusion
What is Fusion?
Combining components by melting together and cooling (while stirring) until congealed
What is the term for combining components by melting and cooling while stirring until congealed?
Fusion
For what type of base would you use Mineral oil as a Levigating agent?
Oily bases
Bases with oil as the external phase
For an oily base ointment or one where an oil is the external phase, what type of Levigating agent would you use?
Mineral oil
For bases where water is the external phase what Levigating agent would you use?
Glycerin
Glycerin is used as a Levigating agent for what type of bases?
Bases with water as the external phase
How much Levigating agent should be used?
Levigating agent should be in equal volume to the solid material
What type of spatula should be used for the preparation of ointments?
A long one with a broad base
When is fusion used?
For bases that contain solids of a greater melting point
Solid medications that are readily soluble in melted bases
What type of ointment preparation is most ideal for a base that contains solids of a higher melting point?
Fusion
What type of ointment preparation is used for solid medications that are readily soluble in melted bases?
Fusion
How do you perform Fusion?
Melt the oil phases separately starting with the highest melting point
The water phase is heated separately to a temp > the temp of the oil phase
The two phases are combined by agitation
Volatile materials are added after cooling
Author
kyleannkelsey
ID
214736
Card Set
PHA 327 - Exam 2 - Ointments 3
Description
PHA 327 - Exam 2 - Ointments 3
Updated
4/21/2013, 4:21:04 AM
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