Pharm Review Final

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Author:
saraherin
ID:
214912
Filename:
Pharm Review Final
Updated:
2013-04-22 18:50:44
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Review
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Description:
Level I pharm review
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  1. Corticosteroids =
    Block or alter the chemical reaction associated with the inflammatory response
  2. Salicylates =
    • Aspirin 
    • block inflammatory response- Inhibit synthesis of prostaglandins 

    • antipyretic 
    • analgesic effect (pain-blocking)
  3. Ibuprofen =
    • NSAID - anti-inflammatory
    • blocks 1 & 2 receptor sites  
    • mild-moderate pain/fever
    • Rheumatiod arthritis
  4. NSAID's contra-indications:
    • Impaired Kidney 
    • Stomach ulcers 
    • Bleeding 
    • may interfere with diuretics
  5. Acetaminophen =
    • Tylenol 
    • Thermoregulatory cells of hypothalamus 
    • Vasodilation/sweating 
    • pain/fever (flu, cold)
    • prophylaxis in children for DPT shots
    • musculoskeletal pain from arthritis
  6. Acetaminophen Contraindications/ Adverse Effects :
    • Pregnancy / lactation 
    • Hard on Liver, not easily metabolized 

    • Hepatotoxicity (liver)
    • Increase bleeding with oral anticoagulants
  7. Anxiolytic =
    Prevents feelings of tension or fear
  8. Sedative =
    Calm and make patients unaware on environment
  9. Hypnotic =
    cause sleep
  10. Minor Tranquilizers =
    Produce a state of tranquility in anxious patients
  11. Benzodiazepine Agent/prototype drug=
    Diazepam
  12. Benzodiazopine Action =
    acts on Limbic system and RAS (movement/motivation)

    • Make GABA more effective 
    • Causes interference with neurons firing
  13. Benzodiazopine Indications:
    • Anxiety disorder 
    • Alcohol withdrawal 
    • Hyperexcitability / agitation 
    • Pre-operative relief of anxiety
  14. Benzodiazopine pharmacokinetics :
    • Lipid soluble and well distributed throughout the body
    • Well absorbed from GI tract
  15. Benzodiazopine contraindications/ Cautions:
    • Psychosis 
    • Acute narrow angle glaucoma 
    • Acute alcohol intoxication 
    • shock, coma
  16. Reversal agent for Diazopines:
    Romazicon
  17. Benzodiazopine drug-drug interactions:
    Increase CNS depression with alcohol
  18. Barbiturates agent/prototype =
    Phenobarbital 

    • Inhibits conduction of the ascending RAS
    • Depress cerebral cortex
    • Drepress motor output
  19. Barbiturate drugs are used in what settings?
    • Pre-anesthesia
    • Seizures
    • Peak in 20-60 minutes
  20. Contraindications of Barbiturates:
    • History of addiction
    • Respiratory distress
    • Hepatic / Nephritis impairment
    • Porphyria - accumulation of normal body chemicals
  21. Barbiturates Adverse Reactions:
    • Somnolence (sleepy more than drowsy)
    • Ataxia (gait)
    • Vertigo
  22. Barbiturates Drug-Drug interactions:
    • Increase CNS depressant with alcohol, antihistamines, and other tranquilizers 
    • MOA may increase serum levels 
    • Decrease the effect of anticoagulants, digoxin, oral contraceptives
  23. Valum, Zanex, and Ativan are what types of drugs?
    Benzodiazepines
  24. Muscle spasticity =
    • the result of damage to neurons within the CNS.
    • stay stretched or damaged
  25. This muscle reactant enters the muscle directly:
    Botulinum Toxins / Dantrolene 

    BOTOX
  26. Muscle relaxants work by ...
    to Lyse or Destroy the spasm, they interfere with the reflexes causing the pain
  27. Centrally acting muscle relaxants are used in cases of ....
    • Spasticity
    • Spinal injury 
    • Diesease
  28. Muscle reactants are contraindicated in _________.

    Cautioned with what conditions:
    Rheumatic disorders 

    • Epilepsy
    • Cardiac dysfuntion 
    • muscle weakness

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