PHA 327 - Exam 2 - Dosage Forms 2

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kyleannkelsey
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214937
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PHA 327 - Exam 2 - Dosage Forms 2
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2013-04-21 21:28:03
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PHA 327 Exam Dosage Forms
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PHA 327 - Exam 2 - Dosage Forms 2
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  1. What examples in class were given for a transdermal drug delivery system where a drug is mixed with a polymer and contained in a membrane?
    • Nitro-Dur
    • Scopolamine
    • Nicotine patches
  2. What type of drug delivery systems fall into the category transdermal patch?
    • Single layer drug in adhesive
    • Multi-layer drug in adhesive
    • Matrix system
    • Reservoir system
  3. Describe a monolithic device:
    • A matrix system
    • Drug is mixed with a polymer to form a matrix of pores
    • Time of drug diffusion represents the time to travel out of the pore matrix
  4. What type of Dissolution-Diffusion controlled drug delivery systems exist?
    • Monolithic
    • Reservoir
    • Degradable
  5. Describe how an osmotic pump works:
    • A drug mixed with the core material is placed inside a semi-permeable membrane.
    • A laser hole is made in the membrane
    • When water osmotically enter the device, it creates pressure and drug leaks from the pore
  6. What type of drug delivery system involved drug mixed with core material in a semipermeable membrane that allows water to osmotically enter and push drug out of a small pore?
    An Osmotic pump
  7. Explain how an effervescent tablet works?
    An effervescent layer of a drug is activated by water, releasing CO2 and eventually dissolving leaving the drug to release into the GI
  8. What is a liposome?
    A closed system of unilammellar or multilamellar natural phospholipid bilayers surrounding an internal aqueous phase
  9. What type of drug delivery system is composed of unilamellar ot multimallelar natural phospholipid bilayers surrounding an aqueous phase?
    Liposome
  10. How is the drug released from a liposome?
    It is taken up by cell and phagocytized, causing release
  11. What is a Physical liposome?
    A temperature or pH sensitive liposome
  12. What type of liposome is temperature of pH sensitive?
    A physical liposome
  13. What is an active liposome?
    An unmodified liposome that gathers in reticulo-endothelial tissue
  14. What type of liposome gathers in reticulo-endothelial tissue?
    An Inactive liposome
  15. What is an Active liposome?
    A liposome with an altered surface, which may include the addition of antibodies, enzymes, Protein A and sugars.
  16. What type of liposome has an altered surface that may include the addition of antibodies, sugars, enzymes or Protein A?
    An Active liposome
  17. Describe how a self-emulsifying drug system works:
    The mixture of oil, surfactant and drug spontaneously form an oil-in-water emulsions in an aqueous environment under gentle agitation
  18. What type of drug delivery system is a mixture of oil, drug and surfactant?
    Self-Emulsifying drug delivery system
  19. What are the advantages of a Self-emulsifying drug delivery system?
    • Improve solubility
    • Enhance lymphatic transport/bioavailability
    • Can be used for acids/bases/neutral drugs
    • Oral administration
  20. What drug delivery system can be used for acidic/basic and neutral drugs, enhances lymphatic transport and bioavailability, improves solubility and is taken orally?
    Self-emulsifying Drug delivery systems
  21. Describe an Amorphous drug delivery system:
    The amorphous drug in a low energy crystal lattice structure is dissolved in readily dissolved into solution
  22. Describe the differences between an amorphous drug and a crystalline drug:
    • Amorphous is less thermodynamically stable than crystalline
    • Amorphous has molecules packed randomly whereas crystalline is uniform
    • Amorphous has a more soluble/ less stable lattice form than crystalline
  23. What is an example of an osmotic pump drug delivery system?
    Oros
  24. What is Oros?
    An Osmotic pump drug delivery system
  25. What is an example of a Liposome?
    Production of monoclonal antibodies
  26. Monolithic devices, Reservoir devices and Degradable systems are all what type of Drug delivery system?
    Dissolution-Diffusion controlled drug delivery systems
  27. What are Reservoir systems?
    Rate controlled membranes
  28. What type of drug delivery system is a rate controlled membrane?
    Reservoir
  29. What is a degradable system?
    Polymers in the drug are degrades by chemical action, releasing the drug at a constant, predetermined rate
  30. What type of drug delivery system has polymers in the dosage form that slowly degrade in the body, releasing the drug at a constant rate?
    Degradable systems

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