PHA 327 - Exam 2 - Dosage Forms 3

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kyleannkelsey
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214938
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PHA 327 - Exam 2 - Dosage Forms 3
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2013-04-21 21:29:18
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PHA 327 Exam Dosage Forms
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PHA 327 - Exam 2 - Dosage Forms 3
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  1. The production of monoclonal antibodies is an example of what type of drug delivery system?
    A liposome
  2. Describe a solid dispersion drug delivery system:
    • A drug delivery system composed of 2 or more solid products
    • 1.) Hydrophilic matrix
    • 2.) Hydrophobic drug
  3. What type of drug delivery system is composed of two solids, a hydrophilic matrix and a hydrophobic drug?
    A solid Dispersion system
  4. What are the two main advantages of a solid dispersion system?
    • Drug stability
    • Dissolution advantage
  5. What three characteristics of a Solid dispersion system give it a dissolution advantage?
    • It has reduced drug particle size
    • The drug is in an amorphous state = increased solubility
    • Enhanced wettability due to the hydrophilic matrix
  6. What two characteristics of a Solid dispersion system give it a stability advantage
    • Low molecular mobility (High Tg)
    • Polymer interaction with the drug through H bonding
  7. What is a liquid controlled release system?
    A controlled release suspension where a polymer is bound to an ionic drug.
  8. What is a Magnetic drug delivery system?
    • Drug delivery system activated by magnetic fields
    • Drugs are bound to porous polymeric beads and magnetic molecules
  9. What is the term for a controlled release suspension where a polymer is bound to an ionic drug that is released in the GI?
    Liquid controlled release system
  10. What diseases are implanted pumps commonly used for?
    • Liver cancer
    • Diabetes
  11. What are the advantages of an implanted pump?
    They can be programmed to deliver precise doses and rates
  12. What are the disadvantages of implanted pumps?
    • Cost
    • Bulky
  13. What is an example of a liquid controlled release system?
    Pennkinetic system
  14. Pennkinetic system is an example of what drug delivery system?
    Liquid controlled release system
  15. What is a respiratory delivery system?
    Nasal sprays that deliver drug to the bronchial trees
  16. What type of system delivers drugs via a spray through the nose to the bronchial tree?
    Respiratory delivery systems
  17. What is the most important drug characteristic for a respiratory drug delivery system?
    Particle size
  18. What examples were given in class for drugs that can utilize respiratory delivery systems?
    • GHRH
    • Vasopressin
  19. Vasopressin and GHRH were discussed in class as being good drugs for what type of delivery system?
    Respiratory delivery
  20. What were potential candidates for Respiratory delivery (as discussed in class)?
    Proteins, Vaccines and Antibiotics used to treat respiratory tract infections
  21. What are some issues with delivery of endogenous neurotransmitters?
    • How to deliver it to the brain
    • How to target specific areas of the brain
  22. The delivery of what is complicated by the issue of delivering the drug to certain areas of the brain?
    Endogenous neurotransmitters
  23. What are possible ways of delivering endogenous neurotransmitters?
    • Intracerebral injection
    • Utilizing pH balance in brain vessels
    • Via food or food supplements
  24. What is an example of a delivery system for endogenous neurotransmitters?
    Lecithin capsules that carry acetylcholine
  25. What type of drug delivery system are lecithin capsules that carry acetylcholine?
    Delivery of endogenous neurotransmitters

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