PHA 327 - Exam 2 - Dosage Forms 4

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kyleannkelsey
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214940
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PHA 327 - Exam 2 - Dosage Forms 4
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2013-04-21 21:32:28
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PHA 327 Exam Dosage Forms
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PHA 327 - Exam 2 - Dosage Forms 4
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  1. What type of drug can be delivered directly via intracerebral injection, via systems that utilize brain vessel pH or via food or supplements?
    Endogenous neurotransmitters
  2. What is a Pulse delivery system?
    • A delivery system made or erodible polymers
    • Each layer of polymer has a different drug loads
    • The drug is released during a skin pore opening electric pulse
  3. What are Hydrogels?
    Three dimensional crosslinked networks of homopolymers, copolymers or macromers
  4. What is the term for a three dimensional, cross-linked network formed from hydrophilic monomers, homopolymers or macromers?
    A hydrogel
  5. Hydrogels can be designed to accept different simuli (T/F)?
    • True
    • They can accept stimuli from:
    • pH, ionic strength, Chemical species, Enzyme-substrates, magnetic, thermal, electrical and Ultrasound irradiation
  6. What type of drug delivery system can be designed to accept stimuli from pH, ions, Chemical agents, Enzyme-substrate interactions, Magnetic fields, Heat, Electricity and ultrasound irradiation?
    Hydrogels
  7. What is diffusion?
    A process of mass transfer via random Brownian motion
  8. What is the process of mass transfer via random Brownian motion called?
    Diffusion
  9. Perfume, Osmosis and Dialysis are all systems that are based on what basic principal?
    Diffusion
  10. What four reasons were given in class for the importance of diffusion to pharmacy?
    • Dissolution of drugs
    • Dialysis
    • Lyophylization
    • Ultra-filtration
  11. What is the equation for Fick’s law of diffusion or Flux?
    • J = dM/(S x dt)
    • M = grams of material passing over the barrier in time t
    • S = cross-section area of barrier
    • J = flux
  12. What is Fick’s first law of diffusion?
    • J = -D (dC/dx)
    • D = diffusion coefficient of the solute (in cm2/sec)
  13. The Diffusion coefficient of Fick’s first law is a function of what five properties?
    • Temp
    • Pressure
    • Conc.
    • Solvent properties
    • Chemical nature of solute
  14. What is Fick’s second law?


    • D = diffusion coefficient of the solute in cm2/sec           
    • t = time           
    • x = position in barrier
  15. What five important applications for Fick’s laws were discussed?
    • 1.) Development of controlled-release dosage forms
    • 2.) Bioavailability of dosage form
    • 3.) lyophilization
    • 4.) Efficiency of dialysis membranes
    • 5.) Physiological phenomena (lung gas exchange, renal filtering)
  16. What equation would you use to predict the bioavailability of a drug via its diffusion coefficient?
    Fick’s law
  17. What equation would you primarily use to calculate the diffusion coefficient?


    • tL = lag-time
    • h = thickness of barrier
    • D = diffusion coefficient

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