PHA 327 - Exam 2 - Suspensions 1
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What a suspension?
Preparations containing minimally soluble, finely divided drug particles dispersed in a liquid
What groups are oral suspensions good for?
- Children, elderly
- b/c easier to swallow
How can oral suspensions be enhanced for children ?
What are two examples of oral suspension?
- Antacid suspension
- Antibacterial oral suspensions
What are common examples of Antacid suspension?
- Sodium bicarbonate
- Aluminum hydroxide
- Aluminum phosphate
What type of suspension is Sodium bicarbonate, aluminum hydroxide and aluminum phosphate?
Oral Antacid suspension
What is an example of an Antibacterial oral suspension?
Amoxicillin suspension is given by what route?
What is an example of an externally applied suspension?
What is the behavior of an externally applied suspension (lotions) when applied to skin?
It dries on the skin after application
What type of preparation is externally applied suspension usually?
What should containers of externally applied suspensions (lotions) state?
- “Shake well before use”
- “For external use only”
What are two types of Injectable preparations (suspensions)?
- Sustained release injectable formulations
- Formulations of drug depots
What type of suspension are sustained release injectable formulations and Drug depots?
Where are drug depots injected?
What is an example of an injectable suspension?
Procaine Penicillin G
Procaine Penicillin G is what type of suspension?
What is a Dry powder for Oral suspension?
A mixture of dry powders to be reconstituted with vehicle prior ro administration
What is the term for a power mixture that intended to be reconstituted prior to use?
Dry powder for oral suspension
What is an example of a dry powder for oral suspension?
- Ampicillin oral suspension
- Cefixime oral suspension
Ampicillin oral suspension and Cefixime oral suspension are what type of suspensions?
Dry powders for Oral suspension
Name the two rectal suspensions discussed in class:
- Barium sulfate for Suspension USP
- Mesalamine (5-aminosalicylic acid)
What type of suspension are Barium sulfate for suspension USP and Mesalamine (5-aminosalicylic acid)?
What is Mesalamine (5-aminosalicylic acid) used for?
Crohn’s disease and ulcerative colitis
What rectal suspension is used to treat Crohn’s disease and Ulcerative Colitis?
Mesalamine (5-aminosalicylic acid)
What is Barium sulfate for suspension used for?
Diagnostic visualization of the GI (oral or rectal)
What rectal suspension is used to visualize the GI?
Barium sulfate for suspension USP
What are the advantages of suspensions (4)?
- Insoluble drugs can be conveniently administered
- Drugs that are unstable in solutions can often be dosed in suspension
- Better for bad tasting drugs
- More effective for drugs whose activity depends on particle surface area
What re the disadvantages of suspensions (4)?
- Uniformity and dose accuracy are difficult (inadequate particle dispersion)
- Sedimentation/Cake formation
- Product is liquid/bulky
- Difficult to formulate
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