PHA 327 - Exam 2 - Suspensions 4

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kyleannkelsey
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214990
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PHA 327 - Exam 2 - Suspensions 4
Updated:
2013-04-22 00:23:52
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PHA 327 Exam Suspensions
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PHA 327 - Exam 2 - Suspensions 4
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  1. What has a protective colloid action on a suspension?
    Polymers
  2. What do polymers do physically in a suspension?
    Adsorb to the particle surface
  3. What large scale machinery is available for making suspensions?
    • Colloid mill
    • Ball mill
    • Pebble mill
  4. What tool would you use in a pharmacy to make a suspension?
    Mortar and pestle
  5. What is the process of making a suspension?
    • Reduce drug powder to desired size
    • Add drug and wetting agent to solution
    • Add suspension agent
    • Add excipients
    • Homogenize
    • Package
  6. What need to be evaluated in a suspension (6)
    • Sedimentation H or V
    • Ease of redispersibility
    • Particle size
    • Rehological measurements
    • Temperature and gravitational stress test
    • Zeta potential determination
  7. What should a suspending agent not do?
    Increase the viscosity considerably
  8. What are the six suspending agents discussed in class?
    • Carboxymethylcellulose
    • Methylcellulose
    • Microcrystalline cellulose
    • Polyvinyl pyrolidone
    • Xanthan gum
    • Bentonite
  9. What are Wetting agents?
    An agent that removes the air from the surface of the particles for easy penetration by the vehicle
  10. What type of material is hard to Wet?
    Hydrophobic materials
  11. Why are hydrophobic particles hard to wet?
    They adsorb air on the surface
  12. What are the three types of Wetting agents discussed in class?
    • Surfactants
    • Hydrocolloids
    • Solvents
  13. What are examples of solvent wetting agents?
    • Alcohol
    • Glycerine
    • Polyethylene Glycol
  14. What are examples of hydrocolloid Wetting agents?
    • Acacia
    • Tragacanth
  15. What are examples of surfactant wetting agents?
    • Polysorbate 80
    • Sodium Lauryl sulfate
  16. What type of wetting agents are polysorbate 80 and sodium lauryl sulfate?
    Surfactant wetting agents
  17. What type of wetting agents are Acacia and Tragacanth?
    Hydrocolloid wetting agents
  18. What type of wetting agents are alcohol, Glycerine and Polyethylene glycol?
    Solvent wetting agents

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