PHA 327 - Exam 2 - Suspensions 4
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What has a protective colloid action on a suspension?
What do polymers do physically in a suspension?
Adsorb to the particle surface
What large scale machinery is available for making suspensions?
- Colloid mill
- Ball mill
- Pebble mill
What tool would you use in a pharmacy to make a suspension?
Mortar and pestle
What is the process of making a suspension?
- Reduce drug powder to desired size
- Add drug and wetting agent to solution
- Add suspension agent
- Add excipients
What need to be evaluated in a suspension (6)
- Sedimentation H or V
- Ease of redispersibility
- Particle size
- Rehological measurements
- Temperature and gravitational stress test
- Zeta potential determination
What should a suspending agent not do?
Increase the viscosity considerably
What are the six suspending agents discussed in class?
- Microcrystalline cellulose
- Polyvinyl pyrolidone
- Xanthan gum
What are Wetting agents?
An agent that removes the air from the surface of the particles for easy penetration by the vehicle
What type of material is hard to Wet?
Why are hydrophobic particles hard to wet?
They adsorb air on the surface
What are the three types of Wetting agents discussed in class?
What are examples of solvent wetting agents?
- Polyethylene Glycol
What are examples of hydrocolloid Wetting agents?
What are examples of surfactant wetting agents?
- Polysorbate 80
- Sodium Lauryl sulfate
What type of wetting agents are polysorbate 80 and sodium lauryl sulfate?
Surfactant wetting agents
What type of wetting agents are Acacia and Tragacanth?
Hydrocolloid wetting agents
What type of wetting agents are alcohol, Glycerine and Polyethylene glycol?
Solvent wetting agents
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