Antineoplastics #3

Card Set Information

Author:
mp
ID:
215177
Filename:
Antineoplastics #3
Updated:
2013-04-22 23:04:26
Tags:
Med Chem III Antineoplastics
Folders:

Description:
Antineoplastics #3
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user mp on FreezingBlue Flashcards. What would you like to do?


  1. Mitotic Inhibitors -- drugs
    • Vincristine
    • Vinblastine
    • Vinorelbine
    • Paclitaxel
    • Docetaxel
  2. Vincristine
    • tubulin inhibitor
    • causes neuropathies
  3. Vinblastine
    • tubluin inhibitor
    • very toxic to bone marrow
    • minimal neurotoxicity
  4. vincristine and vinblastine
    • very painful extravastion
    • 3A4
  5. vinorelbine -- Navelbine
    • granulocytopenia
    • neurotoxicity
  6. Paclitaxel -- Taxol and Docetaxel -- Taxotere
    • acts in G2 to forn microtubule bundles
    • 24 hr infusion
    • metastatic breast cancer
  7. Taxoids
    • Spindle poison
    • cells can't divide
  8. Docetaxel -- Taxotere
    • used in combo with 5-FU and cisplatin
    • 3A4
  9. Cabazitaxel -- Jevtana
    • premedicate with antihistamine, corticosteroids, H2 antagonist
    • 3A4
    • combo with prednisone
  10. Ixabepilone -- Ixempra
    • binds to beta-tubulin and suppresses instability that leads to mitotic phase -- no cell division
    • dosing based on skin surface area
    • 3A4
    • Cardiotoxic
  11. eribulin -- Halaven
    • metastatic breast cancer
    • microtubule dynamics inhibitor
    • nontaxoid, from marine sponge
    • No CYP
  12. Antitumor Antibiotics
    • intercalation -- cytotoxic
    • not cell cycle specific
    • not for treating infections
  13. Antitumor Antibiotics -- classes
    • anthracyclines
    • bleomycin
    • plicamycin
    • mitomycin
    • dactinomycin
    • anthacenediones
    • enediynes
  14. doxorubicin
    • anthracycline -- intercalating agent
    • pee and sweat bright red color
  15. anthracyclines moa and info
    • non-specific cell cycle drugs with max. toxicity in S and G2 phases.
    • intercalation prevents DNA replication
    • cardiotoxicity
    • extreme extravasation
  16. Bleomycins -- info
    • Cu chelating agents
    • minimal myelosuppression
    • pulmonary fibrosis
    • good combo agents
  17. Bleomycin
    • inj for plantar worts
    • cell cycle specific G2 and M phases by inhibiting DNA replication
  18. Mitomycin -- Mitosol
    • prodrug
    • inhibits DNA synthesis via crosslinking guanine and cytosine
  19. dactinomycin -- Cosmegen
    • intercalates DNA preventing DNA synthesis, cell cycle non-specific
    • prevent extravasation
    • natural product
  20. Mitoxantrone
    • tx of MS
    • intercalates
    • severe immunosuppressive
    • pee a blue-green color
  21. Platinum Drugs
    • cell cycle nonspecific agent resulting in DNA cross linking
    • prodrugs
    • marrow suppression
    • No Al containing admin sets
    • Severe N/V
  22. Selenomethionine
    Reduces nephrotoxicity from Cisplatin
  23. Procarbazine -- Matulane
    inhibits transmethylation of t-RNA by methionine
  24. Temozolomide -- Temodar
    prodrug, producing a potent methylation agent, inhibiting the initiation of transcription
  25. Hydroxyurea -- Hydrea
    • off label tx of sickle cell
    • interferes with DNA replicationby inhibiting ribonucleotide reductases

What would you like to do?

Home > Flashcards > Print Preview