Antineoplastics #5

Card Set Information

Author:
mp
ID:
215250
Filename:
Antineoplastics #5
Updated:
2013-04-23 00:42:01
Tags:
Med Chem III Antineoplastics
Folders:

Description:
Antineoplastics #5
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user mp on FreezingBlue Flashcards. What would you like to do?


  1. Cytoprotective agents (3)
    • Amifostine -- Ethyol
    • Dexrazoxane -- Zinecand
    • Mesna sodium -- Mesnex
  2. Amifostine -- Ethyol
    • thiol phosphate prodrug
    • scavenges toxic platinum metabolites
  3. Dexrazoxane -- Zinecand
    • extravasation from IV anthracyclines (doxirubicin)
    • prodrug of EDTA
  4. Mesna sodium -- Mesnex
    • Ifosfamide and cyclophosphamide induced hemorrhagic cystitis
    • thiol group scavenges acrolein
  5. Tretinoin -- Absorica
    • induces maturation of blood cell presursors
    • teratogen
  6. Bexarotene -- Targretin
    • promote cellular differentiation and proliferation
    • teratogen
  7. Imatinib -- Gleevec
    • protein-tyrosine kinase inhibitor
    • metab -- 3A4
    • tyrosine kinase inhibitors -- many drug interactions with 3A4
  8. Temsirolimus -- Torisel
    • prevents phosphorylation and arrests G1 phase and decreases expression of VEGF
    • metab -- 3A4
    • found on drug-eluting stents
  9. Everolimus -- Afinitor
    • prevents phosphorylation and arrests G1 phase and decreases expression of VEGF
    • use caution in p-glycoprotein inibitors
    • 3A4 inducer and inhibitor
  10. Bortezomib -- Velcade
    • boron based 26s proteasome¬†inhibitor
    • painful non life threatening skin rashes
  11. Carfilzomib -- Kyprolis
    tetrapeptide epoxyketone proteasome inhibitor
  12. Vismodegib -- Erivedge
    binds and inhibits Smoothened, a transmembrane protein involved in Hedgehog signal transduction
  13. Vorinostat -- Zolina
    inhibits histone deacetylase
  14. Romidepsin -- Istodax
    • IV depsipeptide agent
    • inhibits histone deacetylase
  15. Elesclomol
    • induces oxidative stress
    • orphan drug for metastatic melanoma
  16. Abiraterone -- Zytiga
    • prostate cancer
    • androgen biosynthesis inhibitor of CYP17
    • stops production of testosterone
  17. Porfirmer -- Photofrin
    • photodynamic therapy
    • photosensitizing agent by laser light generating oxygen free radicals
    • pallative tx for lung cancer
  18. Mitotane -- Lysodren
    • suppresses adrenal fx and production of adrenal steroids
    • can cause brain damage and depression
    • similar to DDT
  19. PEG
    • low systemic toxicity
    • improves biological half life
  20. PEG-L-Asparaginase -- Oncaspar
    • immunogenicity of protein is decreased
    • All tumor cells lack L-asparagine synthase
    • depletes L-asparagine fomr tumor cell -- cytotoxic
  21. Palifermin -- Kepivance
    • reduces severe mucositis
    • increases proliferation differentiation and migration of epithelial cells

What would you like to do?

Home > Flashcards > Print Preview