Bio 121

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Author:
JoyAP7
ID:
215274
Filename:
Bio 121
Updated:
2013-04-23 13:03:13
Tags:
molecular
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Description:
molecular biology
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  1. What are the four components to all signals?
    • 1. Ligand Biochemistry and Mode of Delivery
    • 2. Receptor
    • 3. Second Messenger Cascade
    • 4. Target Mechanisms
  2. What are the sources of solubilized molecules?
    • A. Paracrine signaling- local, short distance, intercellular
    • B. Endocrine signaling- systemic, long distance, intercellular
    • C. Synaptic signaling- paracrine? endocrine?both?
    • D. Exchange of cytosolic components
    • E. Juxacrine Signaling
  3. What does synaptic signaling do?
    • 1. Adaptation for systemic regulation in Animalia
    • 2. Nerves can act long-range like endocrine system
    • 3. Synapse is shortest paracrine delivery of all and, thus, can affect as few as a single cell
    • 4. Cool electrical control of signal release
  4. What are the transmembrane proteins?
    • A. Integrin, cadherin, delta, notch, eph,ephrin
    • B. G-protein-linked receptors 
    • C. Enzyme-linked receptors
    • D. Specialized growth factors receptors
    • E. Ion channel-linked receptors
  5. What are the Intracellular Receptors?
    • A. Nuclear receptors- transcriptional activators
    •     1. steroid hormone receptors, vitamin-D     receptors
    •     2. thyroid hormone receptors
    •     3. retinoic acid receptors
    •     4. orphan receptors
    • B. Soluble gas receptors- NO,CO
  6. Trimeric G-protein structure and function
    • 1. Three protein subunits (different genes)- α,β,γ
    • 2. Electrostatically bound to receptor as inactive trimeric form: α-subunit has GDP bound
    • 3. Activation and Inactivation regulate downstream activity

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