MedChem quiz 9 drugs for Exam 4

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MedChem quiz 9 drugs for Exam 4
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2013-04-24 16:12:08
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MedChem quiz 9 drugs for Exam 4
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  1. cytoprotective agent that will scavenge the acrolein byproduct that is renal/bladder toxic
    Mesna sodium - Mesnex
  2. boronic acid functional group 26 proteasome inhibitor
    Bortezomib - Velcade
  3. anti-mitotic spindle poison that stabilizes and promotes microtubule assembly
    Docetaxel - Taxotere
  4. aromatase inhibitor for treatment of estrogen dependent neoplasia
    Anastrozole - Arimidex
  5. treatment of extravasation due to leakage of aziridium based alkyation agent into tissue surrounding infusion site
    sodium thiosulfate / ice packs
  6. antidote to intention methotrexate high dosage treatment
    levoleucovorin
  7. CYP2D6 mediated competitive inhibition of metabolism
    Tamoxifen/SSRI drug interaction
  8. prodrug antineoplastic agent that requires CYP 450 activation to generate the nitrogen mustard alkylating species and the renal toxic acrolein byproduct
    Cyclophosphamide - Neosar
  9. inhibitor of protein tyrosine kinase in cancer treatment
    Imatinib mesylate - Gleevec
  10. alkylating agent used for bone marrow ablation therapy prior to bone marrow transplantation from a donor
    Busulfan - Myleran
  11. biotec product that is used to counter the severe mucositis inflammation of the mouth and intestinal tract from chemotherapy and radiation treatment
    Palifermin - Kepivance
  12. folic acid antagonist that is trapped once inside the cell following polyglutamate attachment
    Pemetrexed - Alimta
  13. responsible for the metabolism of all the protein tyrosine kinase inhibitors used to treat neoplasm
    CYP3A4
  14. leukopenia inducing antineoplastic agent that is used in sickle cell disease
    Hydroxyurea - Hydrea
  15. pyrimidine based antimetabolite drug
    Fludribine - Fludara
  16. Anti-emetic agent example of the type of drug everyone on chemotherapy/radiation should receive
    Metoclopramide - Reglan
  17. cytoprotective agent used to scavenge renal toxic platinum based excretion products
    Amifostine - Ethyol
  18. topoisomerase inhibitor
    Etoposide - Toposar
  19. cytoprotective agent used specifically to counter the cardiotoxicity of anthracyclines such as doxirubicin
    Dexrazoxane - Savene
  20. anti-neoplastic antibiotic with minimal bone marrow suppression properties
    Bleomycin - Blenoxane
  21. metoclopramide - Reglan
    anti-emetic agent example of the type of drug everyone on chemo/radiation should receive
  22. anastrozole - Arimidex
    aromatase inhibitor for treatment of estrogen dependent neoplasia
  23. palifermin - Kepivance
    biotec product that is used to counter the severe mucositis inflammation of the mouth and intestinal tract from chemotherapy and radiation treatment
  24. dexrazoxane - Savene
    cytoprotective agent used specifically to counter the cardiotoxicity of anthracyclines such as doxirubicin
  25. CYP3A4
    responsible for the metabolism of all the protein tyrosine kinase inhibitors used to treat neoplasia
  26. etoposide - Toposar
    topoisomerase inhibitor
  27. hydroxyurea - Hydrea
    leukopenia inducing antineoplastic agent that is used in sickle cell disease
  28. bortezomib - Velcade
    boronic acid functional group 26 proteasome inhibitor
  29. docetaxel - Taxotere
    anti-mitotic spindle poison that stabilizes and promotes microtubule assembly
  30. imatinib mesylate - Gleevec
    inhibitor is protein tyrosine kinase in cancer treatment
  31. amifostine - Ethyol
    cytoprotective agent used to scavenge renal toxic platinum based excretion products
  32. fludribine - Fludara
    pyrimidine based antimetabolite drug
  33. levoleucovorin
    antidote to intentional methotrexate high dosage treatment
  34. cyclophosphamide - Neosar
    prodrug antineoplastic agent that requires CYP450 activation to generate the nitrogen mustard alkylating species and the renal toxic acrolein byproduct
  35. bleomycin - Blenoxane
    anti-neoplastic antibiotic with minimal bone marrow suppression properties
  36. mesna sodium - Mesnex
    cytoprotective agent that will scavenge the acrolein byproduct that is renal/bladder toxic
  37. tamoxifen/SSRI drug interaction
    CYP2D6 mediated competitive inhibition of metabolism
  38. pemetrexed - Alimta
    folic acid antagonist that is trapped once inside the cell following polyglutamate attachment
  39. busulfan - Myleran
    alkylating agent used for bone marrow ablation therapy prior to bone marrow transplantation from a donor
  40. sodium thiosulfate / ice packs
    treatment of extravasation due to leakage of aziridium based alkyation agent into tissue surrounding infusion site

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