suspension

Card Set Information

Author:
jcu1
ID:
215767
Filename:
suspension
Updated:
2013-04-25 11:05:34
Tags:
DD3 final
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Description:
DD3 final
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  1. particle size of coarse dispersion
    10-50 μm
  2. particle size of fine dispersion
    0.5-10 μm
  3. percentage of solids in a dilute suspension
    2-10%
  4. percentage of solids in a concentrated suspension
    50%
  5. ophthalmic solutions shouldn't exceed what size
    10 microns
  6. equation for change in surface free energy
    ΔG = γSLΔA
  7. 3 ways to reduce the sedimentation
    • decrease particle size
    • add suspending agents
    • increase viscosity
  8. what can be used as a flocculating agent
    • electrolyte
    • charged surfactant
    • charged polymer
  9. what type of surfactant is most commonly used as a wetting agent
    non-ionic surfactants with an HLB 7-10
  10. most widely used surfactant
    polysorbate 80
  11. what does polysorbate 80 do to zeta potential of drug particles
    • reduces zeta potential and stabilizes the suspension
    • through a steric mechanism
  12. most commonly used solvent
    • areaalcohol
    • glycerin
    • PEG
    • polypropylene glycol

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