Resp Meds

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Resp Meds
2013-04-28 13:38:03
Resp meds

Resp Meds
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  1. Antihistimine mechanism
    H1 anatagonist (competes for H1 receptors)
  2. Antihistimine use
    Prevent and treat allergic responses(more effective in preventing than reversing so give early) Hypnotic safe non narcotic, Anticholinergic effects, Anti-emetic, 2nd generation has longer duration
  3. Antihistimine side effects
    Drowsiness, vertigo, sedation(1st generation), hypotension, palpitations, arrhythmia, dryness of mouth, thicken bronchial secretions, anorexia, n/v, diarrhea/constipation, urinary retention, dysuria
  4. Antihistimine Cautions
    • Glaucoma, hyperthyroidism, HTN, Cardiac/renal disease, asthma, COPD, peptic ulcer disease, BPH, pregnancy, Misuse(rebound congestion)
    • DDI: Inderal anatagonizes antihistimines
    • ***contraindicated in the presence of Acute asthma attacks and lower resp diseases***
  5. Antihistimine Generations
    1st Generation (sedating): Benadryl(diphenhydramine), chlorpheneramine

    2nd Generation (non-sedating): Allegra, Zrytec, Claritin
  6. Antihistimine Alternative
    • Intranasal glucocorticoid(steroids) for seasonal allergic rhinitis. They can 1-3 weeks to kick in. They also have decongestant effect
    • *budesonide(Rhinocort)
    • *flticason(Flonase)
    • *mometasone(Nasonex)
  7. Antihistimine Drug Interactions
    Possibly with Erythromycin, MAOI's, CNS depressants
  8. Decogestant 3 groups
    • 1. Adrenergic(constrict blood vessles and shirnk engorged mucous membranes, used the most)
    • 2. Anticholinergic
    • 3. Topical Steroids
  9. Decongestant nasal spray warning
    Over use (more than 3-5 days) can cause rebound effect and increase swelling
  10. Decongestant Oral Drugs
    • Pseudophedrine(Sudafed)- NO REBOUND EFFECT, takes longer to work but lasts longer than topical sprays.
    • ***Can cause adverse effects HTN, CNS stimulation and palpitations***
    • Watch caffeine intake
    • *Contraindicstions are DM, Cardiac/thyroid disease, prostatis
    • ****Pseudoephedrine being replaced with phenylephrine because of meth making****
  11. Decongestant use
    Systemic relief of allergic rhinitis, sinusitis, colds and flu
  12. Antitussive Use
    • *used to stop or reduce coughing(reflex center in medulla)
    • *maybe used in cases where coughing is harmful EX. after hernia surgery
  13. Antitussive Opioids
    • Codiene and Hydrocodone raise cough threshold in the CNS, usually used in combination, effective in small doses, less change is habit forming, most need prescription.
    • **contraindicated of pt's with severs resp disorders such as asthma and COPD**
    • Codiene sulfate, Hydrocodone bitartrate (Hycodane)
  14. Antitussive Non-Opioids
    • Common s/e=dizziness and GI
    • less effective, non sedating, no analgesic properties.
    • Dextromethorphan(OTC cough syrups), benzonatate (Tessalon), diphenhydramine (Benylin)
  15. Expectorant effects
    Increase resp tract fluid, decrease viscosity of bronchial and tracheal secretions. In simple terms break down and thin out secretions to cough it up and spit it out
  16. Expectorant use
    Persistent cough, mucus plugs, common cold, bronchitis
  17. Expectorant Drug
    Guaifenesin (Robitussin)
  18. Expectorant S/E
    allergy to drug itself, n/v, anorexia, pregnancy category c