Resp Meds

H1 anatagonist (competes for H1 receptors)

Prevent and treat allergic responses(more effective in preventing than reversing so give early) Hypnotic safe non narcotic, Anticholinergic effects, Anti-emetic, 2nd generation has longer duration

Drowsiness, vertigo, sedation(1st generation), hypotension, palpitations, arrhythmia, dryness of mouth, thicken bronchial secretions, anorexia, n/v, diarrhea/constipation, urinary retention, dysuria

• Glaucoma, hyperthyroidism, HTN, Cardiac/renal disease, asthma, COPD, peptic ulcer disease, BPH, pregnancy, Misuse(rebound congestion)
• DDI: Inderal anatagonizes antihistimines
• ***contraindicated in the presence of Acute asthma attacks and lower resp diseases***

1st Generation (sedating): Benadryl(diphenhydramine), chlorpheneramine

2nd Generation (non-sedating): Allegra, Zrytec, Claritin

• Intranasal glucocorticoid(steroids) for seasonal allergic rhinitis. They can 1-3 weeks to kick in. They also have decongestant effect
• *budesonide(Rhinocort)
• *flticason(Flonase)
• *mometasone(Nasonex)

Possibly with Erythromycin, MAOI's, CNS depressants

• 1. Adrenergic(constrict blood vessles and shirnk engorged mucous membranes, used the most)
• 2. Anticholinergic
• 3. Topical Steroids

Over use (more than 3-5 days) can cause rebound effect and increase swelling

• Pseudophedrine(Sudafed)- NO REBOUND EFFECT, takes longer to work but lasts longer than topical sprays.
• ***Can cause adverse effects HTN, CNS stimulation and palpitations***
• Watch caffeine intake
• *Contraindicstions are DM, Cardiac/thyroid disease, prostatis
• ****Pseudoephedrine being replaced with phenylephrine because of meth making****

Systemic relief of allergic rhinitis, sinusitis, colds and flu

• *used to stop or reduce coughing(reflex center in medulla)
• *used for NONPRODUCTIVE COUGH ONLY
• *maybe used in cases where coughing is harmful EX. after hernia surgery

• Codiene and Hydrocodone raise cough threshold in the CNS, usually used in combination, effective in small doses, less change is habit forming, most need prescription.
• **contraindicated of pt's with severs resp disorders such as asthma and COPD**
• Codiene sulfate, Hydrocodone bitartrate (Hycodane)

• Common s/e=dizziness and GI
• less effective, non sedating, no analgesic properties.
• Dextromethorphan(OTC cough syrups), benzonatate (Tessalon), diphenhydramine (Benylin)

Increase resp tract fluid, decrease viscosity of bronchial and tracheal secretions. In simple terms break down and thin out secretions to cough it up and spit it out

Persistent cough, mucus plugs, common cold, bronchitis

Guaifenesin (Robitussin)

allergy to drug itself, n/v, anorexia, pregnancy category c