Describe how APP can be differentially processed and identify the resulting products. (ie, What is responsible for the processing of APP, how does it result in different products etc...)
- Two pathways (one healthy, one not):
- 1. Alpha: healthy pathway, in which APP cleaved by Alpha secretase, then gamma secretase. After these are cleaved, p3 subunit is released
- 2. Beta: DISEASE causing, in which APP cleaved by beta secretase, then gamma secretase. The end result is ABeta42 production. This ABeta42 is what causes the buildup of plaque in the brain.