- a loop diuretic; works in the thick ascending loop of henleinhibits symporter (cotransporter) Na+/K/2Cl- which inhibits reabsorption of Na+ and Cl-
moa: Na+ and Cl- cnc are disrupted and affect the reabsorption of other ions... leads to hypertonic renal medulla and inc.
urine output very important for maintaining Na+ infiltrate (infiltrate comes from glomerulus to bowman's to PCT, etc.)
* Loop diuretics are the MOST POTENT DIURETICS(most potent diuretics work at 1. thick ascending loop of henle (fucosamide) and 2. DCT, sice most of Na+ reabsorption occurs here)