BIOL 404-Exam 4-Muscle 9

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  1. What muscular disease is one of the most frequent genetic disease, effecting 1:3500 males?
    Muscular dystrophy
  2. Describe the pathogenesis of muscular dystrophy:
    Progressive degeneration of skeletal and cardiac muscle, leading to death by cardiac and respiratory failure
  3. What is the etiology of Muscular dystrophy?
    absence or defect in the X-linked gene that is associated with costamere proteins in striated muscle, particularly dystrophin
  4. What disease is characterized by a genetic abnormality in costamere proteins in striated muscle?
    Muscular dystrophy
  5. What is the name of the costamere protein associated with Duchennemuscular dystrophy?
  6. What type of inheritance does Duchenne Muscular dystrophy have?
    X-linked recessive
  7. What are costameres?
    Clustered structural and regulatory proteins that attach Z-disks of out myofibrils to the extracellular membrane and Sarcolemma
  8. What is Myasthenia Gravis?
    Reduced nicotinic receptors at motor end plate
  9. What is the normal cause of Myasthenia Gravis?
    Auto-antibodies attach the nicotinic receptors
  10. What are the three common treatments for Myasthenia Gravis?
    • Immune suppression therapy (glucocorticoids)
    • Acetylcholine esterase inhibitors (neostygmine)
    • Plasmapheresis
  11. What muscular disease would you treat with immune suppressants, AChase inhibitors or Plasmapheresis?
    Myasthenia Gravis
  12. What muscular disease would you treat with Neostygmine or glucocorticoids?
    Myasthenia Gravis
  13. What is Plasmapheresis?
    Plasma replacement
  14. What muscular disease would you treat with plasmapheresis?
    Myasthenia Gravis
  15. Is Myasthenia Gravis more common in men or women?
  16. Is muscular dystrophy more common in men or women?
  17. What is the morbidity of Myasthenia Gravis?
Card Set:
BIOL 404-Exam 4-Muscle 9
2013-05-01 15:48:20
BIOL 404 Exam Muscle

BIOL 404-Exam 4-Muscle 9
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