BIOL 404-Exam 4-Muscle 10
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What is the action of Curare?
- Competitively binds to Nicotinic receptors without opening their ion channels
- Cannot be destroyed by Acetylcholine esterase
What were the three non-depolarizing neuromuscular junction blocking drugs discussed in class?
What are Curare, Vecuronium and Rocuronium?
Non-depolarizing neuromuscular junction blockers
What is the advantage of Vecuroniuma nd Rocuronium?
Longer acting than Curare
What muscle related drug can cause death by asphyxiation?
Curare, as it can inhibit muscles required for breathing
Other than non-depolarizing nicotinic competitive inhibitors, what alternate mechanisms are there for blocking neuromuscular transmission?
inhibition of acetylcholineesterase
What are examples of toxins that inhibit acetylcholinesterase?
- Found in nerve gas and fertilizers
What is Succinylcholine?
- Depolarizing/Desensitizing acetylcholine receptors Antagonist
- Works similarly to acetylcolinesterase inhibitors
Succinylcholine works similarly to what other drugs?
What is the action of Succinylcholine?
Depolarizing/Desensitizing acetylcholine receptors Antagonist
What is the generally potency of Botulism toxin?
- One of the most potent toxins
- Need very little to produce and effect
What bacteria produces Botulism?
What is Botulism toxin?
An enzyme that breaks down the SNARE complex rquired for fusion of ACh vesicles with axon terminal
What is the name for the substance that breaks down SNARE complexes, required for ACh binding to the axon terminal?
What are common uses for Botulism toxin?
- Overactive extraocular muscles
- Excessive sweat gland activity
- Treatment for migraines
Describe the structure of smooth muscle:
- 1-2 um wide
- 50-400 um long
- Spindle shaped
How does the size of smooth muscle compare to the size of skeletal muscle?
What are the dimensions of skeletal muscle?
10-100 um wide and can be tens of centimeters long
How many nuclei do smooth muscle cells contain?
When do smooth muscle cells cease to divide?
Never, can continually divide throughout a lifetime
What filament component is not found in Smooth Muscle?
What type of cells would you not expect to find Troponin?
Smooth muscle cells
What filament components would you expect to find in smooth muscle?
What are think filaments in smooth muscle cells anchored to?
- Plasma membrane or Dense bodies
Describe the banding pattern of smooth muscle cells?
No banding pattern due to lack of sarcomeres and myofibrils
What type of muscle cell does not have myofibrils, sarcomeres or a banding pattern?
Smooth muscle cells
What is the mechanism for smooth muscle contraction?
Sliding filament mechanism
Where are smooth muscles found?
Surrounding hollow organs that undergo changes in volume
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