Regulation of Metabolism

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Anonymous
ID:
217106
Filename:
Regulation of Metabolism
Updated:
2013-05-01 17:59:59
Tags:
tubberly biochem3
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Description:
Just glycolysis, gluconeogenesis, pyruvate dehydrogenase, and TCA cycle...Man these suck
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  1. Hexokinase
    • In skeletal muscle
    • Activators: None
    • Inhibitors: G-6P
  2. Glucokinase
    • Hexokinase D or Hexokinase IV
    • 50 times lower glucose affinity than hexokinase
    • In liver
    • Activators: None
    • Inhibitors: F-6P
  3. PFK
    • In skeletal muscle
    • Activators: AMP
    • Inhibitors: ATP, low pH
    • In the liver
    • "PFK1"
    • Activators: F-2,6-BP
    • Inhibitors: ATP, Citrate
  4. PFK2
    • In the liver
    • Kinase domain creates F-2,6-BP
    • When unphosphorylated
    • Activators: Pi
    • Inhibitors: Citrate
    • Phosphatase domain reduces levels of F-2,6-BP when phosphorylated by PKA
    • Activators: None
    • Inhibitors: F-6P
  5. Pyruvate Kinase
    • In skeletal muscle or liver
    • More active when unphosphorylated, but can be phosphorylated by PKA
    • Activators: F-1,6-BP
    • Inhibitors: ATP, Alanine
  6. Fructose-1,6-bisphosphatase
    • Activators: Citrate
    • Inhibitors: AMP, F-2,6-BP
  7. Pyruvate Caboxylase
    • Activators: Acetyl CoA
    • Inhibitors: ADP
  8. Phosphoenol-pyruvate Carboxykinase
    • Activators: None
    • Inhibitors: ADP
  9. Pyruvate Dehydrogenase
    • Can be phosphorylated by Pyruvate Dehydrogenase Kinase
    • Can be dephosphorylated by Pyruvate Dehydrogenase Phosphatase
    • Active when unphosphorylated
  10. Pyruvate Dehydrogenase Kinase
    • Activators: Acetyl CoA, NADH
    • Inhibitors: ADP, Pyruvate
  11. Pyruvate Dehydrogenase Phosphatase
    • Activators: Ca2+
    • Inhibitors: None
  12. Dihydrolipoamide Acetyltransferase
    Activators: CoA-SH
    Inhibitors: Acetyl CoA
  13. Dihydrolipoamide Dehydrogenase
    • Activators: NAD+
    • Inhibitors: NADH
  14. Citrate Synthase
    • Activators: None
    • Inhibitors: ATP
  15. Isocitrate Dehydrogenase
    • In mammals
    • Activators: Ca2+, ADP
    • Inhibitors: ATP, NADH
    • In E. coli
    • It can be phosphorylated by isocitrate dehydrogenase kinase, but it is activated when unphosphorylated by isocitrate dehydrogenase phosphatase
  16. Isocitrate Dehydrogenase Kinase
    • Activators: None
    • Inhibitors: Isocitrate, Oxaloacetate,  3-Phosphoglycerate, Phosphoenolpyruvate, Pyruvate
  17. Isocitrate Dehydrogenase Phosphatase
    Activators: Isocitrate, Oxaloacetate, 3-Phosphoglycerate, Phosphoenolpyruvate, Pyruvate
  18. α-ketoglutarate Dehydrogenase
    • Activators: None
    • Inhibitors: ATP, NADH, Succinyl CoA

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